Translational Research of Today,
Standard Care of Tomorrow


Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine

Generate HYPOTHESIS

design the experiment

measure

analyze

validate
ONGOING PROJECTS

DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.

THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS

DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM

RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members

Prof. Dr. Pablo Sinues Ph.D.
Head of Translational Medicine Research Group


Mélina Richard
Lead Research Coordinator, Research Associate

Kim Fabienne Arnold
PhD Candidate

Amanda Gisler
PhD Candidate
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System

Jiafa Zeng
PhD Candidate
PROJECTS

Mo Awchi
PhD Candidate
PROJECTS

Noemi Künstle
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function


DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow

Rapid Detection of Staphylococcus aureus and Streptococcus pneumoniae by Real-Time Analysis of Volatile Metabolites
AUTHORS: Alejandro Gómez-Mejia, Arnold Kim, Bär Julian, Kapil Dev Singh, Thomas C. Scheier, Silvio D. Brugger, Annelies S. Zinkernagel, Pablo Sinues JOURNAL INFO: iScience (under review) YEAR: 2022 LINK:...
An Interoperability Framework for Multicentric Breath Metabolomic Studies
AUTHORS: Gisler, Amanda; Singh, Kapil Dev; Zeng, Jiafa; Osswald, Martin; Awchi, Mo; Decrue, Fabienne; Schmidt, Felix; Sievi, Noriane; Chen, Xing; Usemann, Jakob; Frey, Urs; Kohler, Malcolm; Li, Xue; Sinues, Pablo. JOURNAL INFO: iScience (under review) YEAR: 2022...
Pollen exposure is associated with risk of respiratory symptoms during the first year of life
AUTHORS: Gisler A, Eeftens M, de Hoogh K, Vienneau D, Salem Y, Yammine S, Jakob J, Gorlanova O, Decrue F, Gehrig R, Frey U, Latzin P, Fuchs O, Usemann J; BILD study group JOURNAL INFO: Allergy. 2022 Mar 18 YEAR: 2022 LINK: https://doi.org/10.1111/all.15284
Combination of Exhaled Breath Analysis with Parallel Lung Function and FeNO Measurements in Infants
AUTHORS: Fabienne Decrue, Kapil Dev Singh, Amanda Gisler, Mo Awchi, Jiafa Zeng, Jakob Usemann, Urs Frey, Pablo Sinues. JOURNAL INFO: Anal. Chem. 2021, 93, 47, 15579–15583 YEAR: 2021 LINK: https://doi.org/10.1021/acs.analchem.1c02036
Real-Time Monitoring of Metabolism during Exercise by Exhaled Breath
AUTHORS: Osswald M, Kohlbrenner D, Nowak N, Spörri J, Sinues P, Nieman D, Sievi NA, Scherr J, Kohler M. JOURNAL INFO: Metabolites. 2021; 11(12):856. YEAR: 2021 LINK: https://doi.org/10.3390/metabo11120856
Quantification of volatile organic compounds by secondary electrospray ionization-high resolution mass spectrometry
AUTHORS: ChaoLiu, JiafaZeng, PabloSinues, MingliangFang, ZhenZhou, XueLi JOURNAL INFO: Analytica Chimica Acta, Volume 1180, 2 October 2021, 338876 YEAR: 2021 LINK: https://pubs.acs.org/doi/10.1021/acs.analchem.1c00509
Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Nonvolatile Drugs from Blood to Breath
AUTHORS: Xing ChenXing Chen, Keda Zhang, Zhihong Yin, Mingliang Fang, Weidan Pu, Zhening Liu, Lei Li, Pablo Sinues, Robert Dallmann, Zhen Zhou, Xue Li JOURNAL INFO: Anal. Chem. 2021, 93, 12, 5005–5008 YEAR: 2021 LINK:...
Rapid and reversible control of human metabolism by individual sleep states
AUTHORS: Nora Nowak, Thomas Gaisl, Djordje Miladinovic, Ricards Marcinkevics, Martin Osswald, Stefan Bauer, Joachim Buhmann, Renato Zenobi, Pablo Sinues, Steven A. Brown, Malcolm Kohler JOURNAL INFO: Cell Reports, VOLUME 37, ISSUE 4, 109903, OCTOBER 26, 2021 YEAR:...
Increased Impact of Air Pollution on Lung Function in Preterm vs. Term Infants: The BILD Study
AUTHORS: Decrue F, Gorlanova O, Salem Y, Vienneau D, de Hoogh K, Gisler A, Usemann J, Korten I, Nahum U, Sinues P, Schulzke S, Fuchs O, Latzin P, Röösli M, Frey U; BILD7 study group. JOURNAL INFO:Am J Respir Crit Care Med. YEAR: 2021 LINK:...
Personalised therapeutic management of epileptic patients guided by pathway-driven breath metabolomics
AUTHORS: Kapil Dev Singh, Martin Osswald, Victoria C. Ziesenitz, Mo Awchi, Jakob Usemann, Lukas L. Imbach, Malcolm Kohler, Diego García-Gómez, Johannes van den Anker, Urs Frey, Alexandre N. Datta & Pablo Sinues JOURNAL INFO: Communications Medicine Commun...
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