Translational Research of Today,
Standard Care of Tomorrow
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Generate HYPOTHESIS

design the experiment

measure

analyze

validate

DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.

THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS

DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM

RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
Research Group
Members

Prof. Dr. Pablo Sinues Ph.D.
Head of Translational Medicine Research Group


Kim Fabienne Arnold
PhD Candidate
PROJECTS
> Rapid Diagnosis of Infectious Respiratory Diseases by Breath Analysis

Mo Awchi
PhD Candidate
PROJECTS
> Therapeutic Drug Monitoring Guided by Breath Analysis

Amanda Gisler
PhD Candidate
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System

Jiafa Zeng
Ph.D. Candidate
PROJECTS
> Therapeutic Drug Monitoring Guided by Breath Analysis

Dr. Med. Fabienne Decrue
PhD Candidate
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time
Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System


Isabel Gonzalez
Study Nurse
>Therapeutic Drug Monitoring Guided by Breath Analysis

DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow
Pollen exposure is associated with risk of respiratory symptoms during the first year of life
AUTHORS: Gisler A, Eeftens M, de Hoogh K, Vienneau D, Salem Y, Yammine S, Jakob J, Gorlanova O, Decrue F, Gehrig R, Frey U, Latzin P, Fuchs O, Usemann J; BILD study group JOURNAL INFO: Allergy. 2022 Mar 18 YEAR: 2022 LINK: https://doi.org/10.1111/all.15284
Combination of Exhaled Breath Analysis with Parallel Lung Function and FeNO Measurements in Infants
AUTHORS: Fabienne Decrue, Kapil Dev Singh, Amanda Gisler, Mo Awchi, Jiafa Zeng, Jakob Usemann, Urs Frey, Pablo Sinues. JOURNAL INFO: Anal. Chem. 2021, 93, 47, 15579–15583 YEAR: 2021 LINK: https://doi.org/10.1021/acs.analchem.1c02036
Real-Time Monitoring of Metabolism during Exercise by Exhaled Breath
AUTHORS: Osswald M, Kohlbrenner D, Nowak N, Spörri J, Sinues P, Nieman D, Sievi NA, Scherr J, Kohler M. JOURNAL INFO: Metabolites. 2021; 11(12):856. YEAR: 2021 LINK: https://doi.org/10.3390/metabo11120856
Quantification of volatile organic compounds by secondary electrospray ionization-high resolution mass spectrometry
AUTHORS: ChaoLiu, JiafaZeng, PabloSinues, MingliangFang, ZhenZhou, XueLi JOURNAL INFO: Analytica Chimica Acta, Volume 1180, 2 October 2021, 338876 YEAR: 2021 LINK: https://pubs.acs.org/doi/10.1021/acs.analchem.1c00509
Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Nonvolatile Drugs from Blood to Breath
AUTHORS: Xing ChenXing Chen, Keda Zhang, Zhihong Yin, Mingliang Fang, Weidan Pu, Zhening Liu, Lei Li, Pablo Sinues, Robert Dallmann, Zhen Zhou, Xue Li JOURNAL INFO: Anal. Chem. 2021, 93, 12, 5005–5008 YEAR: 2021 LINK:...
Rapid and reversible control of human metabolism by individual sleep states
AUTHORS: Nora Nowak, Thomas Gaisl, Djordje Miladinovic, Ricards Marcinkevics, Martin Osswald, Stefan Bauer, Joachim Buhmann, Renato Zenobi, Pablo Sinues, Steven A. Brown, Malcolm Kohler JOURNAL INFO: Cell Reports, VOLUME 37, ISSUE 4, 109903, OCTOBER 26, 2021 YEAR:...
Increased Impact of Air Pollution on Lung Function in Preterm vs. Term Infants: The BILD Study
AUTHORS: Decrue F, Gorlanova O, Salem Y, Vienneau D, de Hoogh K, Gisler A, Usemann J, Korten I, Nahum U, Sinues P, Schulzke S, Fuchs O, Latzin P, Röösli M, Frey U; BILD7 study group. JOURNAL INFO:Am J Respir Crit Care Med. YEAR: 2021 LINK:...
Personalised therapeutic management of epileptic patients guided by pathway-driven breath metabolomics
AUTHORS: Kapil Dev Singh, Martin Osswald, Victoria C. Ziesenitz, Mo Awchi, Jakob Usemann, Lukas L. Imbach, Malcolm Kohler, Diego García-Gómez, Johannes van den Anker, Urs Frey, Alexandre N. Datta & Pablo Sinues JOURNAL INFO: Communications Medicine Commun...
Real-time pharmacokinetics via online analysis of exhaled breath
AUTHORS: Celia IsabelLópez-Lorente, MoAwchi, PabloSinues, DiegoGarcía-Gómez JOURNAL INFO: Journal of Pharmaceutical and Biomedical Analysis, Volume 205, 25 October 2021, 114311 YEAR: 2021 LINK:...
Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Nonvolatile Drugs from Blood to Breath
AUTHORS: X Chen, K Zhang, Z Yin, M Fang, W Pu, Z Liu, L Li, P Sinues, R Dallmann, ... JOURNAL INFO: Analytical Chemistry 93 (12), 5005-5008 YEAR: 2021 LINK: https://pubs.acs.org/doi/full/10.1021/acs.analchem.1c00509








