Translational Research of Today,
Standard Care of Tomorrow
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Generate HYPOTHESIS

design the experiment

measure

analyze

validate

DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.

THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS

DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM

RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
Research Group
Members

Prof. Dr. Pablo Sinues Ph.D.
Head of Translational Medicine Research Group


Kim Fabienne Arnold
PhD Candidate
PROJECTS
> Rapid Diagnosis of Infectious Respiratory Diseases by Breath Analysis

Mo Awchi
PhD Candidate
PROJECTS
> Therapeutic Drug Monitoring Guided by Breath Analysis

Amanda Gisler
PhD Candidate
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System

Jiafa Zeng
Ph.D. Candidate
PROJECTS
> Therapeutic Drug Monitoring Guided by Breath Analysis

Dr. Med. Fabienne Decrue
PhD Candidate
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time
Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System


Isabel Gonzalez
Study Nurse
>Therapeutic Drug Monitoring Guided by Breath Analysis

DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow
Ambient prenatal air pollution exposure is associated with low cord blood IL-17a in infants
AUTHORS: Olga Gorlanova, Heide Oller, Andrea Marten, Loretta Müller, Jessica Laine-Carmelli, Fabienne Decrue, Yasmin Salem, Danielle Vienneau, Kees de Hoogh, Amanda Gisler, Jakob Usemann, Insa Korten, Sophie Yammine, Uri Nahum, Noemi Künstle, Pablo Sinues, Sven...
Comparison of Plasma Ionization- and Secondary Electrospray Ionization- High-resolution Mass Spectrometry for Real-time Breath Analysis
Comparison of Plasma Ionization- and Secondary Electrospray Ionization- High-resolution Mass Spectrometry for Real-time Breath Analysis AUTHORS: Jiafa Zeng, Alexandra Christen, Kapil Dev Singh, Urs Frey, Pablo Sinues JOURNAL INFO: Chimia 2022 YEAR: 2022 LINK:...
Personalized Medicine, Curated Collections
Human Breath Analysis May Support the Existence of Individual Metabolic Phenotypes AUTHORS: Pablo Martinez-Lozano Sinues, Malcolm Kohler, Renato Zenobi JOURNAL INFO: PLOS ONE, Curated Collections YEAR: 2022 (2013) LINK:...
In vivo detection of metabolic 2H-incorporation upon ingestion of 2H2O
AUTHORS: Arnold, Kim; Chen, Xing; Zhang, Hui; Singh, Kapil Dev; Yin, Zhihong; Yao, Yao; Luan, Tiangang; Sinues, Pablo*; Li, Xue* JOURNAL INFO: Journal of Bio-X Research YEAR: 2022 LINK:...
Rapid Detection of Staphylococcus aureus and Streptococcus pneumoniae by Real-Time Analysis of Volatile Metabolites
AUTHORS: Alejandro Gómez-Mejia, Arnold Kim, Bär Julian, Kapil Dev Singh, Thomas C. Scheier, Silvio D. Brugger, Annelies S. Zinkernagel, Pablo Sinues JOURNAL INFO: iScience YEAR: 2022 LINK: https://doi.org/10.1016/j.isci.2022.105080
An Interoperability Framework for Multicentric Breath Metabolomic Studies
AUTHORS: Gisler, Amanda; Singh, Kapil Dev; Zeng, Jiafa; Osswald, Martin; Awchi, Mo; Decrue, Fabienne; Schmidt, Felix; Sievi, Noriane; Chen, Xing; Usemann, Jakob; Frey, Urs; Kohler, Malcolm; Li, Xue; Sinues, Pablo. JOURNAL INFO: iScience YEAR: 2022 LINK:...
Pollen exposure is associated with risk of respiratory symptoms during the first year of life
AUTHORS: Gisler A, Eeftens M, de Hoogh K, Vienneau D, Salem Y, Yammine S, Jakob J, Gorlanova O, Decrue F, Gehrig R, Frey U, Latzin P, Fuchs O, Usemann J; BILD study group JOURNAL INFO: Allergy. 2022 Mar 18 YEAR: 2022 LINK: https://doi.org/10.1111/all.15284
Combination of Exhaled Breath Analysis with Parallel Lung Function and FeNO Measurements in Infants
AUTHORS: Fabienne Decrue, Kapil Dev Singh, Amanda Gisler, Mo Awchi, Jiafa Zeng, Jakob Usemann, Urs Frey, Pablo Sinues. JOURNAL INFO: Anal. Chem. 2021, 93, 47, 15579–15583 YEAR: 2021 LINK: https://doi.org/10.1021/acs.analchem.1c02036
Real-Time Monitoring of Metabolism during Exercise by Exhaled Breath
AUTHORS: Osswald M, Kohlbrenner D, Nowak N, Spörri J, Sinues P, Nieman D, Sievi NA, Scherr J, Kohler M. JOURNAL INFO: Metabolites. 2021; 11(12):856. YEAR: 2021 LINK: https://doi.org/10.3390/metabo11120856
Quantification of volatile organic compounds by secondary electrospray ionization-high resolution mass spectrometry
AUTHORS: ChaoLiu, JiafaZeng, PabloSinues, MingliangFang, ZhenZhou, XueLi JOURNAL INFO: Analytica Chimica Acta, Volume 1180, 2 October 2021, 338876 YEAR: 2021 LINK: https://pubs.acs.org/doi/10.1021/acs.analchem.1c00509








