Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine

Generate HYPOTHESIS

design the experiment

measure

analyze

validate
ONGOING PROJECTS

DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.

THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS

DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM

RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Core Members



Group Members

Zhihong Yin
PhD Candidate





Former Group Members

Dr. Nachelli Malpica
Former Master Student
PROJECTS
> Development of Standard Operating Procedures for Reproducible Offline Breath Analysis

Dr. Malena Maira Gwerder, MD
Former PhD Candidate
PROJECTS
> Bern Basel Infant Lung Development (BILD) cohort
NEXT
> Assistant Pediatric Doctor at UKBB

Dr. Mo Awchi
Former PhD Candidate
PROJECTS
> Therapeutic Drug Monitoring Guided by Breath Analysis
NEXT
> Senior Operational Specialist at Lonza

Isabel Gonzalez
Former Lead Study Nurse

Dr. Diego Manuel Baur
Former Postdoctoral Researcher

Moor de Waal
Former Student Assistant

Dr. Amanda Gisler
Former PhD Student
PROJECTS
> Standardizing Real-Time Breath AnalysisÂ
> Impact of Air Pollution on the Respiratory System
NEXT
> Management Board Member, LUSTAT Statistics

Fabienne Decrue
Former Responsible Pediatric Doctor
PROJECTS
> Standardisation of Mass Spectrometer Offline Sampling
NEXT
> Pediatric Doctor at UKBB

Dr. Noemi Künstle, MD
Former PhD Candidate
PROJECTS
> Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function

Dr. Jiafa Zeng
Former PhD Candidate

Dr. Kim Fabienne Arnold
Former PhD Student
Circadian variation of the human metabolome captured by real-time breath analysis
AUTHORS: P Martinez-Lozano Sinues, L Tarokh, X Li, M Kohler, SA Brown, R Zenobi, ...JOURNAL INFO: PloS one 9 (12), e114422YEAR: 2014LINK https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114422
Ion mobility spectrometry coupled to laser-induced fluorescence for probing the electronic structure and conformation of gas-phase ions
AUTHORS: VE Frankevich, KV Barylyuk, PML Sinues, R ZenobiJOURNAL INFO: Journal of Analytical Chemistry 69 (13), 1215-1219YEAR: 2014LINK https://link.springer.com/content/pdf/10.1134/S106193481413005X.pdf
Rapid identification of bacteria in blood cultures by mass-spectrometric analysis of volatiles
AUTHORS: C Ballabio, S Cristoni, G Puccio, M Kohler, MR Sala, P Brambilla, ...JOURNAL INFO: Journal of clinical pathology 67 (8), 743-746YEAR: 2014LINK https://jcp.bmj.com/content/jclinpath/67/8/743.full.pdf
Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles
AUTHORS: J He, PML Sinues, M Hollmén, X Li, M Detmar, R ZenobiJOURNAL INFO: Scientific reports 4 (1), 1-6YEAR: 2014LINK https://www.nature.com/articles/srep05196
Rapid Characterization of Oral Bacterial Cultures: P124
AUTHORS: P Sinues, X Li, A Müggler, L Bregy, G Belibasakis, R Zenobi, M Kohler, ...JOURNAL INFO: Respiration 87 (6), 552-553YEAR: 2014LINK...
Determination of Smoking Status by Real-Time Mass Spectrometry: P135
AUTHORS: P Sinues, X Li, N Sievi, R Zenobi, M KohlerJOURNAL INFO: Respiration 87 (6)YEAR: 2014LINK https://www.zora.uzh.ch/id/eprint/131026/1/ZORA131026.pdf
Real-time breath analysis with active capillary plasma ionization-ambient mass spectrometry
AUTHORS: L Bregy, PML Sinues, MM Nudnova, R ZenobiJOURNAL INFO: Journal of breath research 8 (2), 027102YEAR: 2014LINK https://iopscience.iop.org/article/10.1088/1752-7155/8/2/027102/pdf
Mass Spectrometry Research at the Laboratory for Organic Chemistry, ETH Zurich
AUTHORS: K Barylyuk, V Frankevich, AJ Ibáñez, PML Sinues, R ZenobiJOURNAL INFO: CHIMIA International Journal for Chemistry 68 (3), 119-123YEAR: 2014LINK...
Real-Time Analysis of Trace Ambient Vapors by Secondary Electrospray Ionization-Mass Spectrometry
AUTHORS: P SinuesJOURNAL INFO: ETH ZurichYEAR: 2014LINK https://www.research-collection.ethz.ch/handle/20.500.11850/210783
Gesellschaftsnachrichten/Informations de la Société
AUTHORS: A van Breda, JT Annema, MB von Bartheld, SM Choi, J Lee, YS Park, ...JOURNAL INFO: Respiration 87 (4), 352-352YEAR: 2014LINK...
Spin-off company



