Welcome to the SinuesLab

Translational Research of Today,
Standard Care of Tomorrow

RESEARCH

Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine

Generate HYPOTHESIS

Our interdisciplinary team work coordinately to generate working hypotheses to address our clinical questions

design the experiment

Together with our clinical colleagues we design the right experiment to answer our research questions

measure

We use state-of-the-art high resolution-mass spectrometry to map the exhaled metabolome of our patients

analyze

We use sophisticated bioinformatic tools to decode complex datasets.

validate

Our results are further validated and generate further hypotheses to advance answering our research questions.

ONGOING PROJECTS

DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS

In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.

THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS

The objective in this project is to optimize the therapeutic regimen of pediatric patients to maximize efficacy and minimize side effects.

DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM

In this project we combine air pollution models, state-of-the-art lung function tests and our breath metabolomics approach to better understand the detrimental effects of air pollution exposure in children.

RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS

Our objective is to diagnose infectious diseases, with a focus on pneumonia, by combining our high resolution/high mass accuracy real-time breath analysis technology combined with Artificial Intelligence to provide a positive/negative response within 15 minutes.

News

ABOUT US

Research Group
Members

Core Members

Prof. Dr. Pablo Sinues
Prof. Dr. Pablo Sinues

Head

Dr. Kapil Dev Singh
Dr. Kapil Dev Singh

Co-Deputy Head

Dr.sc.med.des. Mélina Richard
Dr.sc.med.des. Mélina Richard

Co-Deputy Head

Group Members

Zhihong Yin
Zhihong Yin

PhD Candidate

Britta Brugger
Britta Brugger

PhD Candidate

Mana Okada Thommen
Mana Okada Thommen

Study Nurse BILD, EBECA

DR. JAKOB USEMANN, MD, PhD
DR. JAKOB USEMANN, MD, PhD

Resident Physician, Postdoctoral Research Fellow

Abigail Gex-Collet
Abigail Gex-Collet

Student Assistant

Former Group Members

Dr. Nachelli Malpica
Dr. Nachelli Malpica

Master student

PROJECTS

> Development of Standard Operating Procedures for Reproducible Offline Breath Analysis

 

Dr. Malena Maira Gwerder, MD
Dr. Malena Maira Gwerder, MD

PhD Candidate

PROJECTS

> Bern Basel Infant Lung Development (BILD) cohort

NEXT

> Assistant Pediatric Doctor at Universitäts-Kinderspital beider Basel (UKBB) in Basel, Switzerland

Dr. Mo Awchi
Dr. Mo Awchi

PhD Candidate

PROJECTS

> Therapeutic Drug Monitoring Guided by Breath Analysis

NEXT

> Senior Operational Specialist at Lonza in Basel, Switzerland

Isabel Gonzalez
Isabel Gonzalez

Lead Study Nurse

 

 

Dr. Diego Manuel Baur
Dr. Diego Manuel Baur

Postdoc

Moor de Waal
Moor de Waal

Student Assistant

Dr. Amanda Gisler
Dr. Amanda Gisler

PhD Student

PROJECTS

> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis

> Deciphering the Impact of Air Pollution Exposure for the Respiratory System

NEXT

> Member of the management board at LUSTAT Statistics in Lucerne, Switzerland

 

Dr. Noemi Künstle, MD
Dr. Noemi Künstle, MD

PhD Candidate

PROJECTS

> Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function

Dr. Jiafa Zeng
Dr. Jiafa Zeng

PhD Candidate

Dr. Kim Fabienne Arnold
Dr. Kim Fabienne Arnold

PhD Student

PROJECTS

> Rapid Diagnosis of Infectious Respiratory Diseases by Breath Analysis

NEXT

> Medical Affairs Manager at Biomed AG in Dübendorf , Switzerland

PUBLICATIONS

Experimental validation of a high resolution nano-DMA

2004

AUTHORS: E Ramiro, M Sánchez, F Ramiro, J Fernández De La Mora, ...JOURNAL INFO: Journal of Aerosol Science 35, 749-758YEAR: 2004LINK https://www.sciencedirect.com/science/article/pii/S0021850204001144?via%3Dihub

SPINOFF

Spin-off company

Deep Breath Intelligence A.G. is a spin-off company of the University of Basel co-founded by Prof. Pablo Sinues.
DBI’s vision is to uncover the full potential of Molecular Breath Analysis to advance precision medicine and make it available for general health care.
COLLABS
FUNDING