Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Core Members
Group Members
Zhihong Yin
PhD Candidate
DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow
Diego Manuel Baur
Postdoc
Former Group Members
Noemi Künstle
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
Jiafa Zeng
PhD Candidate
Amanda Gisler, PhD
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System
Kim Fabienne Arnold, PhD
Metabolic trajectories during treatment of diabetic ketoacidosis described by breath analysis
AUTHORS: Mo Awchi, Kapil Dev Singh, Sara Bachmann-Brenner, Marie-Anne Burckhardt, Melanie Hess, Urs Zumsteg, Jiafa Zeng, Alexandre N Datta, Urs Frey, Gabor Szinnai, Pablo Sinues JOURNAL INFO: Hormone Research in Paediatrics. 2023, 96, 180-180. YEAR: 2023 LINK:...
UHPLC-MS/MS-Based Identity Confirmation of Amino Acids Involved in Response to and Side Effects from Antiseizure Medications
AUTHORS: Mo Awchi, Pablo Sinues, Alexandre N. Datta, Diego García-Gómez, and Kapil Dev Singh* JOURNAL INFO: Journal of Proteome Research. 2023, 22, 3, 990–995 YEAR: 2023 LINK: https://doi.org/10.1021/acs.jproteome.2c00835
Ambient prenatal air pollution exposure is associated with low cord blood IL-17a in infants
AUTHORS: Olga Gorlanova, Heide Oller, Andrea Marten, Loretta Müller, Jessica Laine-Carmelli, Fabienne Decrue, Yasmin Salem, Danielle Vienneau, Kees de Hoogh, Amanda Gisler, Jakob Usemann, Insa Korten, Sophie Yammine, Uri Nahum, Noemi Künstle, Pablo Sinues, Sven...
Comparison of Plasma Ionization- and Secondary Electrospray Ionization- High-resolution Mass Spectrometry for Real-time Breath Analysis
Comparison of Plasma Ionization- and Secondary Electrospray Ionization- High-resolution Mass Spectrometry for Real-time Breath Analysis AUTHORS: Jiafa Zeng, Alexandra Christen, Kapil Dev Singh, Urs Frey, Pablo Sinues JOURNAL INFO: Chimia 2022 YEAR: 2022 LINK:...
Personalized Medicine, Curated Collections
Human Breath Analysis May Support the Existence of Individual Metabolic Phenotypes AUTHORS: Pablo Martinez-Lozano Sinues, Malcolm Kohler, Renato Zenobi JOURNAL INFO: PLOS ONE, Curated Collections YEAR: 2022 (2013) LINK:...
In vivo detection of metabolic 2H-incorporation upon ingestion of 2H2O
AUTHORS: Arnold, Kim; Chen, Xing; Zhang, Hui; Singh, Kapil Dev; Yin, Zhihong; Yao, Yao; Luan, Tiangang; Sinues, Pablo*; Li, Xue* JOURNAL INFO: Journal of Bio-X Research YEAR: 2022 LINK:...
Rapid Detection of Staphylococcus aureus and Streptococcus pneumoniae by Real-Time Analysis of Volatile Metabolites
AUTHORS: Alejandro Gómez-Mejia, Arnold Kim, Bär Julian, Kapil Dev Singh, Thomas C. Scheier, Silvio D. Brugger, Annelies S. Zinkernagel, Pablo Sinues JOURNAL INFO: iScience YEAR: 2022 LINK: https://doi.org/10.1016/j.isci.2022.105080
An Interoperability Framework for Multicentric Breath Metabolomic Studies
AUTHORS: Gisler, Amanda; Singh, Kapil Dev; Zeng, Jiafa; Osswald, Martin; Awchi, Mo; Decrue, Fabienne; Schmidt, Felix; Sievi, Noriane; Chen, Xing; Usemann, Jakob; Frey, Urs; Kohler, Malcolm; Li, Xue; Sinues, Pablo. JOURNAL INFO: iScience YEAR: 2022 LINK:...
Pollen exposure is associated with risk of respiratory symptoms during the first year of life
AUTHORS: Gisler A, Eeftens M, de Hoogh K, Vienneau D, Salem Y, Yammine S, Jakob J, Gorlanova O, Decrue F, Gehrig R, Frey U, Latzin P, Fuchs O, Usemann J; BILD study group JOURNAL INFO: Allergy. 2022 Mar 18 YEAR: 2022 LINK: https://doi.org/10.1111/all.15284
Combination of Exhaled Breath Analysis with Parallel Lung Function and FeNO Measurements in Infants
AUTHORS: Fabienne Decrue, Kapil Dev Singh, Amanda Gisler, Mo Awchi, Jiafa Zeng, Jakob Usemann, Urs Frey, Pablo Sinues. JOURNAL INFO: Anal. Chem. 2021, 93, 47, 15579–15583 YEAR: 2021 LINK: https://doi.org/10.1021/acs.analchem.1c02036
Spin-off company
