Welcome to the SinuesLab

Translational Research of Today,
Standard Care of Tomorrow

RESEARCH

Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine

Generate HYPOTHESIS

Our interdisciplinary team work coordinately to generate working hypotheses to address our clinical questions

design the experiment

Together with our clinical colleagues we design the right experiment to answer our research questions

measure

We use state-of-the-art high resolution-mass spectrometry to map the exhaled metabolome of our patients

analyze

We use sophisticated bioinformatic tools to decode complex datasets.

validate

Our results are further validated and generate further hypotheses to advance answering our research questions.

ONGOING PROJECTS

DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS

In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.

THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS

The objective in this project is to optimize the therapeutic regimen of pediatric patients to maximize efficacy and minimize side effects.

DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM

In this project we combine air pollution models, state-of-the-art lung function tests and our breath metabolomics approach to better understand the detrimental effects of air pollution exposure in children.

RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS

Our objective is to diagnose infectious diseases, with a focus on pneumonia, by combining our high resolution/high mass accuracy real-time breath analysis technology combined with Artificial Intelligence to provide a positive/negative response within 15 minutes.

News

Martin Röösli

MartinRoosli

New findings from the BILD cohort indicate that preterm infants are more susceptibility to prenatal #AirPollution exposure than term infants, leading to increased impairment of postnatal lung function... 3 Retweets

Raquel

Raquel_Rouco

Finally out! If you want to know more about how a single enhancer loss produces cell-specific alterations eventually leading to clubfoot phenotype don't miss the revised version of our story in @Natur... 2 Retweets

Jasper Boeddinghaus

J_Boeddinghaus

Extremely proud of my wife Fabienne Decrue who has finished her MD-PhD @ukbbkinderspit1 @SinuesLab @SwissTPH with highest praise while being a caring mom and pregnant with our 2nd child. Latest: @ATSB... 1 Retweets

Sinues Lab

SinuesLab

@HGallartAyala Thank you Hector! It was great discussing science face-to-face with you.

Sinues Lab

SinuesLab

@swiss_society Big thank you to the entire #Metabolomics and #MassSpec communities. It has been such an honor. 1 Likes 1 Retweets

Sinues Lab

SinuesLab

Is it feasible to measure #breath from patients, incapable of performing exhalation maneuvers, including infants, for #metabolomic purposes? Our latest publication in @an_chem, provides a perspective... 5 Likes 2 Retweets

The Nobel Prize

NobelPrize

BREAKING NEWS:
The 2021 #NobelPrize in Physiology or Medicine has been awarded jointly to David Julius and Ardem Patapoutian “for their discoveries of receptors for temperature and touch.” https://t.... 10.5K Retweets

Swiss Business Hub

SBH_USA

And the winner is… Switzerland! Our country has led the ranking of the Global Innovation Index since 2011 steadily and continues to top the table. #GII2018 https://t.co/nBFZbfRlzf https://t.co/zsSVXs0... 2 Retweets

Sinues Lab

SinuesLab

We are celebrating 50 years since double Nobel Leareate Linus Pauling et al. published their landmark PNAS paper on the detection of metabolites in human breath. The inspiring piece of work uncapped a... 3 Likes

Sinues Lab

SinuesLab

A succesful day at the _Unibasel research day, presenting our posters and having an inspiring ta....

A succesful day at the @DBE_Unibasel research day, presenting our posters and having an inspiring talk! 🫁 https://t.co/6WQExwMz9m 4 Likes

CSIC Divulga

CSICdivulga

26/08/1743. #UnDíaComoHoy nacía en París Antoine Lavoisier, precursor de la química moderna. Descubre los principales hitos y aplicaciones de esta disciplina con 'Entre Moléculas', una de las #exposic... 33 Retweets

Deep Breath Intelligence

the_dbi

Good and impressive news are spreading globally.
Regarding the recent publication in communication medicine on Personalised therapeutic management for epileptic patients, here an article from indi... 3 Retweets

Communications Medicine

CommsMedicine

Singh et al. perform a breath #metabolomics study in patients with #epilepsy taking antiseizure medications, with breath analysis enabling prediction of systemic drug concentrations, drug response &am... 3 Retweets

Sinues Lab

SinuesLab

We are happy to share this educational video
explaining our #research at @ukbbkinderspit1 @DBE_Unibasel @UniBasel_en
on #BreathAnalysis #Metabolomics, published with @SpringerNature in @CommsMedicin... 4 Likes 4 Retweets

Sinues Lab

SinuesLab

Can you perform pharmacokinetic studies via #breathanalysis? A collaboration review with the SinuesLab and colleagues at @usal put the advances in this domain in perspective. https://t.co/KHrztBG1Wv 2 Likes

Swiss Metabolomics Society

swiss_society

The next Swiss Metabolomics Society & Partners online seminar will be on August 30, 2021 I 12:00-13:00 Prof. Gérard Hopfgartner, University of Geneva will present. Just checkout our homepage https... 5 Retweets

Sinues Lab

SinuesLab

Our latest paper on breath #metabolomics and #epilepsy was highlighted in a news article from @UniBasel_en. A little insight into the work behind the publication!
Breath test to determine correct... 3 Likes

Communications Medicine

CommsMedicine

💡 NEW RESEARCH! Singh et al. perform a breath #metabolomics study in patients with #epilepsy taking antiseizure medications, with breath analysis enabling prediction of systemic drug concentrations, d... 6 Retweets

Sinues Lab

SinuesLab

We are delighted to share our latest #research at @ukbbkinderspit1 @DBE_Unibasel @UniBasel_en on #BreathAnalysis #Metabolomics #epilepsy, published with @SpringerNature in @CommsMedicine https://t.co/... 7 Likes 1 Retweets

Deep Breath Intelligence

the_dbi

DBI`s CEO, Christian Zwicky was interviewed for Tagesschau at SRF (Schweizer Radio und Fernsehen) about our breath technology and analysis for Covid19 and other diseases.
Check out the broadcast!
... 1 Retweets

Swiss Metabolomics Society

swiss_society

Don't forget to join our next Swiss Metabolomics Society & Partners online seminar tomorrow (12:00 – 13:00). It is directly accessible via link on our homepage (without registration) https://t.co/... 2 Retweets

Gary Siuzdak

kadzuis

All you need to know in one figure. Juliana Ivanisevic @unil & @MartinGiera depict why metabolites are at the center of our biochemical universe https://t.co/kflmnBMzYf. Metabolites are the glue t... 103 Retweets

Communications Medicine

CommsMedicine

Our first articles are now live! Read the @CommsMedicine editorial published today: https://t.co/WksKfKyWPS https://t.co/2vWUM8H9dX 29 Retweets

RAICEX

raicex_es

¡Estamos de estreno 📣 ! Ya podéis acceder a nuestra web https://t.co/9AKl4aTyPO Ahí podréis encontrar información como:
🌍 Asociaciones miembro
👥 Equipo y organización
👉 Suscripción newslet... 14 Retweets

Ilaria Belluomo

Ilaria_Bell

Deadline for podium abstracts is next week!
Don't miss it!
#msacl https://t.co/SfK49aEZhs 2 Retweets

MSACL

Podium abstracts are due this week! Share your work with the #MassSpectrometry & Advances in the Clinical Lab community at the virtual European Congress in September. Early-career and global submi... 14 Retweets

Sinues Lab

SinuesLab

There is another _society lunch webinar coming up! This time about non-targeted LC-MS workflows ....

There is another @swiss_society lunch webinar coming up! This time about non-targeted LC-MS workflows for chemical characterization of complex matrices. Join us on the 14th of July at 12:00! https://t...

Swiss Business Hub

SBH_USA

@the_dbi and @Bayer collaborate on the SPRAY-SMART study of a new nasal drug for Obstructive Sleep Apnea Syndromes (OSAS).
Read more:
https://t.co/4KaunmYNtR 2 Retweets

Deep Breath Intelligence

the_dbi

Top 15 Biotech Startups in Switzerland.
DBI is one of them!
https://t.co/yHCLU4m4VH
#BioDigital #Innosuisse #Switzerland #Startup #ETH #UKBB #USZ #SGE #EDA #Breathanalysis #AI #ML #Datascience... 1 Retweets

Deep Breath Intelligence

the_dbi

Collaboration with China Jinan-University
A joint project is about to start with Jinan-University at Guangzhou in China.
#JinanUniversity #Guangzhou #China #collaboration #healtcare #AI #ML #mass... 1 Retweets

Sinues Lab

SinuesLab

The before-mentioned seminar, ''Metabolic Landscape of the Mammalian Digestive Tract'' is now open for registration! Date: June 15th at 12:00 CEST🧐 https://t.co/R0Qq2TB0aX

Sinues Lab

SinuesLab

The digestive tract is full of unexplored territory. What do we see when we combine high-throughput #metabolomics with 16S rRNA sequencing to zoom in into the mammalian digestive tract? Save the date... 3 Likes 1 Retweets

Sinues Lab

SinuesLab

We are not sure if anyone's following all #cryptocurrency drama that is currently going on.. However, let's take a step back and consider the underlying technology. Can we use #blockchain technology... 1 Likes 1 Retweets

Sinues Lab

SinuesLab

Will breath analysis become a potential tool for #PrecisionMedicine? Only time can tell. This @NatureConf on the #Metabolism, however, will definitely add value to our fundamental understanding of the... 3 Likes 1 Retweets

Deep Breath Intelligence

the_dbi

DBI was recently assessed by Innosuisse and got accepted for the three-year ‘Core Coaching’ program. This allows DBI to get access to different coaches from the Innosuisse coaching pool. https://t.co/... 1 Retweets

Swiss National Science Foundation

snsf_ch

Call for Postdoc.Mobility
Expand your research experience with a stay abroad. Submission deadline: 1 August 2021.
https://t.co/ROIkctYKBR 26 Retweets

Sinues Lab

SinuesLab

Hot off the press! Influenza A virus infection induces changes in metabolism which may be associated mostly with glyoxylate/dicarboxylate metabolism in vivo, captured by SESI-HRMS. A nice collaboratio... 1 Likes

Sinues Lab

SinuesLab

We would like to welcome a new team member! Alexandra will join our group for 6 months performing her bachelor thesis on breath analysis. Before her bachelor's, she was an apprentice at Paul Scherrer...

Sinues Lab

SinuesLab

Recently our PI, Pablo Sinues, was featured in this
@an_chem paper on the mechanism of venlafaxine, an antidepressant, being transported from blood to breath. Showing that pharmacokinetics studies c... 2 Likes

Sinues Lab

SinuesLab

Hello Twitter! The Sinues Lab is now active! Our Lab's research activity include #BreathAnalysis #Exhalomics #Metabolomics and #Bioinformatics https://t.co/FBHvovSrea 6 Likes 1 Retweets

ABOUT US

Research Group
Members

Prof. Dr. Pablo Sinues Ph.D.

Head of Translational Medicine Research Group

pablo.sinues@ukbb.ch

+41 617 042 949

Dr. Kapil Dev Singh Ph.D.

Senior Scientist

kapil.singh@ukbb.ch

+41 61 704 29 48

Amanda Gisler

PhD Candidate

amanda.gisler@ukbb.ch

+41 61 704 27 84

PROJECTS

> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis

> Deciphering the Impact of Air Pollution Exposure for the Respiratory System

Kim Fabienne Arnold

PhD Candidate

kim.arnold@ukbb.ch

+41 617 042 949

PROJECTS

> Rapid Diagnosis of Infectious Respiratory Diseases by Breath Analysis

Mélina Richard

Research Coordinator, PhD Candidate

melina.richard@ukbb.ch

+41 61 704 14 11

PROJECTS

> Breath Metabolomics of Placebo Effects

Jiafa Zeng

PhD Candidate

jiafa.zeng@ukbb.ch

+41 61 704 25 76

PROJECTS

> Therapeutic Drug Monitoring Guided by Breath Analysis

Mo Awchi

PhD Candidate

mohamad.awchi@ukbb.ch

+41 61 704 28 98

PROJECTS

> Therapeutic Drug Monitoring Guided by Breath Analysis

Mana Okada Thommen

Study Nurse BILD, EBECA

mana.okada@ukbb.ch

+41 61 704 10 41

DR. JAKOB USEMANN, M.D. Ph.D.

Resident Physician, Postdoctoral Research Fellow

Jakob.Usemann@ukbb.ch

+41 61 704 22 91

Isabel Gonzalez

Lead Study Nurse

isabel.gonzalez@ukbb.ch

+41 61 704 29 43

+41 61 704 29 42

Noemi Künstle

PhD Candidate

noemi.kuenstle@ukbb.ch

+41 61 704 19 67

PROJECTS

>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function

PUBLICATIONS

Monitoring peppermint washout in the breath metabolome by secondary electrospray ionization-high resolution mass spectrometry

2021

AUTHORS: J Lan, A Gisler, T Bruderer, P Sinues, R ZenobiJOURNAL INFO: Journal of breath research 15 (2), 026003YEAR: 2021LINK: https://iopscience.iop.org/article/10.1088/1752-7163/ab9f8a/pdf

In vivo monitoring of volatile metabolic trajectories enables rapid diagnosis of influenza A infection

2021

AUTHORS: Z Yin, W Huang, KD Singh, Z Chen, X Chen, Z Zhou, Z Yang, P Sinues, ...JOURNAL INFO: Chemical Communications 57 (39), 4791-4794YEAR: 2021LINK: https://pubs.rsc.org/en/content/articlehtml/2021/cc/d1cc01061a

Validation of breath biomarkers for obstructive sleep apnea

2021

AUTHORS: N Nowak, A Engler, S Thiel, AS Stoeberl, P Sinues, R Zenobi, M KohlerJOURNAL INFO: medRxivYEAR: 2021LINK: https://www.medrxiv.org/content/medrxiv/early/2021/03/24/2021.03.16.21253612.full.pdf

Circadian Metabolomics from Breath

2021

AUTHORS: SA Brown, P SinuesJOURNAL INFO: Circadian Clocks, 149-156YEAR: 2021LINK https://link.springer.com/protocol/10.1007%2F978-1-0716-0381-9_11

A benchmarking protocol for breath analysis: the peppermint experiment

2020

AUTHORS: B Henderson, DM Ruszkiewicz, M Wilkinson, JD Beauchamp, ...JOURNAL INFO: Journal of breath research 14 (4), 046008YEAR: 2020LINK https://iopscience.iop.org/article/10.1088/1752-7163/aba130/pdf

Real-time breath analysis of exhaled compounds upon peppermint oil ingestion by secondary electrospray ionization-high resolution mass spectrometry: technical aspects

2020

AUTHORS: A Gisler, J Lan, KD Singh, J Usemann, U Frey, R Zenobi, P SinuesJOURNAL INFO: Journal of Breath Research 14 (4), 046001YEAR: 2020LINK https://iopscience.iop.org/article/10.1088/1752-7163/ab9f8b/pdf

Real-time breath analysis reveals specific metabolic signatures of COPD exacerbations

2019

AUTHORS: MT Gaugg, Y Nussbaumer-Ochsner, L Bregy, A Engler, N Stebler, T Gaisl, ...JOURNAL INFO: Chest 156 (2), 269-276YEAR: 2019LINK https://www.sciencedirect.com/science/article/pii/S0012369219300625

Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry

2019

AUTHORS: KD Singh, G Tancev, F Decrue, J Usemann, R Appenzeller, P Barreiro, ...JOURNAL INFO: Analytical and bioanalytical chemistry 411 (19), 4883-4898YEAR: 2019LINK https://link.springer.com/article/10.1007/s00216-019-01764-8

Real-time breath analysis of antiepileptic drugs

2019

AUTHORS: KD Singh, V Ziesenitz, J Usemann, U Frey, J van den Anker, A Datta, ...JOURNAL INFO: Archives of Disease in Childhood 104 (6), e55-e55YEAR: 2019LINK https://adc.bmj.com/content/archdischild/104/6/e55.1.full.pdf

Progress towards Therapeutic Drug Monitoring via breath analysis

2019

AUTHORS: KD Singh, V Ziesenitz, J Usemann, J Van Den Anker, U Frey, ...JOURNAL INFO: Archives of Disease in Childhood 104 (6), e9-e9YEAR: 2019LINK https://adc.bmj.com/content/archdischild/104/6/e9.2.full.pdf

SPINOFF

Spin-off company

Deep Breath Intelligence A.G. is a spin-off company of the University of Basel co-founded by Prof. Pablo Sinues.

DBI’s vision is to uncover the full potential of Molecular Breath Analysis to advance precision medicine and make it available for general health care.