Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Prof. Dr. Pablo Sinues Ph.D.
Head of Translational Medicine Research Group
Mélina Richard
Lead Research Coordinator, Research Associate
+41 61 704 14 11
PROJECTS
> Placebolomics; Breath Metabolomics of Placebo Effects
> Breath Metabolomics of Pain and Stress
Jiafa Zeng
PhD Candidate
PROJECTS
Mo Awchi
PhD Candidate
PROJECTS
Zhihong Yin
PhD Candidate
PROJECTS
Noemi Künstle
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow
Former Group Members
Amanda Gisler, PhD
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System
Kim Fabienne Arnold, PhD
Quantification of volatile organic compounds by secondary electrospray ionization-high resolution mass spectrometry
AUTHORS: ChaoLiu, JiafaZeng, PabloSinues, MingliangFang, ZhenZhou, XueLi JOURNAL INFO: Analytica Chimica Acta, Volume 1180, 2 October 2021, 338876 YEAR: 2021 LINK: https://pubs.acs.org/doi/10.1021/acs.analchem.1c00509
Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Nonvolatile Drugs from Blood to Breath
AUTHORS: Xing ChenXing Chen, Keda Zhang, Zhihong Yin, Mingliang Fang, Weidan Pu, Zhening Liu, Lei Li, Pablo Sinues, Robert Dallmann, Zhen Zhou, Xue Li JOURNAL INFO: Anal. Chem. 2021, 93, 12, 5005–5008 YEAR: 2021 LINK:...
Rapid and reversible control of human metabolism by individual sleep states
AUTHORS: Nora Nowak, Thomas Gaisl, Djordje Miladinovic, Ricards Marcinkevics, Martin Osswald, Stefan Bauer, Joachim Buhmann, Renato Zenobi, Pablo Sinues, Steven A. Brown, Malcolm Kohler JOURNAL INFO: Cell Reports, VOLUME 37, ISSUE 4, 109903, OCTOBER 26, 2021 YEAR:...
Increased Impact of Air Pollution on Lung Function in Preterm vs. Term Infants: The BILD Study
AUTHORS: Decrue F, Gorlanova O, Salem Y, Vienneau D, de Hoogh K, Gisler A, Usemann J, Korten I, Nahum U, Sinues P, Schulzke S, Fuchs O, Latzin P, Röösli M, Frey U; BILD7 study group. JOURNAL INFO:Am J Respir Crit Care Med. YEAR: 2021 LINK:...
Personalised therapeutic management of epileptic patients guided by pathway-driven breath metabolomics
AUTHORS: Kapil Dev Singh, Martin Osswald, Victoria C. Ziesenitz, Mo Awchi, Jakob Usemann, Lukas L. Imbach, Malcolm Kohler, Diego García-Gómez, Johannes van den Anker, Urs Frey, Alexandre N. Datta & Pablo Sinues JOURNAL INFO: Communications Medicine Commun...
Real-time pharmacokinetics via online analysis of exhaled breath
AUTHORS: Celia IsabelLópez-Lorente, MoAwchi, PabloSinues, DiegoGarcía-Gómez JOURNAL INFO: Journal of Pharmaceutical and Biomedical Analysis, Volume 205, 25 October 2021, 114311 YEAR: 2021 LINK:...
Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Nonvolatile Drugs from Blood to Breath
AUTHORS: X Chen, K Zhang, Z Yin, M Fang, W Pu, Z Liu, L Li, P Sinues, R Dallmann, ... JOURNAL INFO: Analytical Chemistry 93 (12), 5005-5008 YEAR: 2021 LINK: https://pubs.acs.org/doi/full/10.1021/acs.analchem.1c00509
Monitoring peppermint washout in the breath metabolome by secondary electrospray ionization-high resolution mass spectrometry
AUTHORS: J Lan, A Gisler, T Bruderer, P Sinues, R ZenobiJOURNAL INFO: Journal of breath research 15 (2), 026003YEAR: 2021LINK: https://iopscience.iop.org/article/10.1088/1752-7163/ab9f8a/pdf
In vivo monitoring of volatile metabolic trajectories enables rapid diagnosis of influenza A infection
AUTHORS: Z Yin, W Huang, KD Singh, Z Chen, X Chen, Z Zhou, Z Yang, P Sinues, ...JOURNAL INFO: Chemical Communications 57 (39), 4791-4794YEAR: 2021LINK: https://pubs.rsc.org/en/content/articlehtml/2021/cc/d1cc01061a
Validation of breath biomarkers for obstructive sleep apnea
AUTHORS: N Nowak, A Engler, S Thiel, AS Stoeberl, P Sinues, R Zenobi, M KohlerJOURNAL INFO: medRxivYEAR: 2021LINK: https://www.medrxiv.org/content/medrxiv/early/2021/03/24/2021.03.16.21253612.full.pdf
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