Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Core Members
Group Members
Zhihong Yin
PhD Candidate
Malena Maira Gwerder, MD
PhD Candidate
Diego Manuel Baur
Postdoc
Nachelli Malpica
Master student
PROJECTS
Development of Standard Operating Procedures for Reproducible Offline Breath Analysis
Former Group Members
Noemi Künstle, MD, PhD
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
Jiafa Zeng, PhD
PhD Candidate
Amanda Gisler, PhD
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System
Kim Fabienne Arnold, PhD
Preservation of exhaled breath samples for analysis by off-line SESI-HRMS: proof-of-concept study
AUTHORS: Rosa A Sola-Martínez, Jiafa Zeng, Mo Awchi, Amanda Gisler, Kim Arnold, Kapil Dev Singh, Urs Frey, Manuel Cánovas Díaz, Teresa de Diego Puente, Pablo Sinues JOURNAL INFO: Journal of Breath Research. 2023, 18.1: 011002 YEAR: 2023 LINK:...
Real-Time Volatile Metabolomics Analysis of Dendritic Cells
AUTHORS: Kim Arnold, Philippe Dehio, Jonas Lötscher, Kapil Dev Singh, Diego García-Gómez, Christoph Hess, Pablo Sinues*, and Maria L. Balmer* JOURNAL INFO: Anal. Chem. 2023, 95, 25, 9415–9421 YEAR: 2023 LINK:...
Late Breaking Abstract – Prenatal exposure to air pollution affects newborns’ autophagy, senescence and remodelling proteins
AUTHORS: Olga Gorlanova, Heide Oller, Uri Nahum, Noemi Künstle, Loretta Müller, Andrea Marten, Céline Rüttimann, Danielle Vienneau, Kees De Hoogh, David Schürmann, Carla Rebeca Da Silva Sena, Martin Röösli, Pablo Sinues, Sven Schulzke, Ruth Steinberg, Jakob Usemann,...
Late Breaking Abstract – Differences in autophagy marker levels at birth in preterm vs. term infants
AUTHORS: Noëmi Künstle, Olga Gorlanova, Andrea Marten, Loretta Müller, Pawan Sharma, Martin Röösli, Pablo Sinues, David Schürmann, Céline Rüttimann, Carla Rebeca Da Silva Sena, Uri Nahum, Jakob Usemann, Ruth Steinberg, Sophie Yammine, Sven Schulzke, Philipp Latzin,...
Prediction of systemic free and total valproic acid by off-line analysis of exhaled breath in epileptic children and adolescents
AUTHORS: Mo Awchi, Kapil Dev Singh, Patricia E Dill, Urs Frey, Alexandre N Datta, Pablo Sinues JOURNAL INFO: J. Breath Res. 17 046013 YEAR: 2023 LINK: https://doi.org/10.1088/1752-7163/acf782
Breath-based therapeutic drug monitoring method
AUTHORS: Kapil Dev Singh, Amanda Gisler, Martin Osswald, Malcolm Kohler, Johannes Van Den Anker, Nicolas Von Der Weid, Urs Frey, Alexandre Datta, Pablo Sinues YEAR: 2023 LINK: https://patents.google.com/patent/US20230277125A1/en
Metabolic trajectories during treatment of diabetic ketoacidosis described by breath analysis
AUTHORS: Mo Awchi, Kapil Dev Singh, Sara Bachmann-Brenner, Marie-Anne Burckhardt, Melanie Hess, Urs Zumsteg, Jiafa Zeng, Alexandre N Datta, Urs Frey, Gabor Szinnai, Pablo Sinues JOURNAL INFO: Hormone Research in Paediatrics. 2023, 96, 180-180. YEAR: 2023 LINK:...
UHPLC-MS/MS-Based Identity Confirmation of Amino Acids Involved in Response to and Side Effects from Antiseizure Medications
AUTHORS: Mo Awchi, Pablo Sinues, Alexandre N. Datta, Diego García-Gómez, and Kapil Dev Singh* JOURNAL INFO: Journal of Proteome Research. 2023, 22, 3, 990–995 YEAR: 2023 LINK: https://doi.org/10.1021/acs.jproteome.2c00835
Ambient prenatal air pollution exposure is associated with low cord blood IL-17a in infants
AUTHORS: Olga Gorlanova, Heide Oller, Andrea Marten, Loretta Müller, Jessica Laine-Carmelli, Fabienne Decrue, Yasmin Salem, Danielle Vienneau, Kees de Hoogh, Amanda Gisler, Jakob Usemann, Insa Korten, Sophie Yammine, Uri Nahum, Noemi Künstle, Pablo Sinues, Sven...
Comparison of Plasma Ionization- and Secondary Electrospray Ionization- High-resolution Mass Spectrometry for Real-time Breath Analysis
Comparison of Plasma Ionization- and Secondary Electrospray Ionization- High-resolution Mass Spectrometry for Real-time Breath Analysis AUTHORS: Jiafa Zeng, Alexandra Christen, Kapil Dev Singh, Urs Frey, Pablo Sinues JOURNAL INFO: Chimia 2022 YEAR: 2022 LINK:...
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