Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Core Members
Group Members
Zhihong Yin
PhD Candidate
DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow
Diego Manuel Baur
Postdoc
Former Group Members
Noemi Künstle
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
Jiafa Zeng
PhD Candidate
Amanda Gisler, PhD
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System
Kim Fabienne Arnold, PhD
Validation of breath biomarkers for obstructive sleep apnea
AUTHORS: N Nowak, A Engler, S Thiel, AS Stoeberl, P Sinues, R Zenobi, M KohlerJOURNAL INFO: medRxivYEAR: 2021LINK: https://www.medrxiv.org/content/medrxiv/early/2021/03/24/2021.03.16.21253612.full.pdf
Circadian Metabolomics from Breath
AUTHORS: SA Brown, P SinuesJOURNAL INFO: Circadian Clocks, 149-156YEAR: 2021LINK https://link.springer.com/protocol/10.1007%2F978-1-0716-0381-9_11
A benchmarking protocol for breath analysis: the peppermint experiment
AUTHORS: B Henderson, DM Ruszkiewicz, M Wilkinson, JD Beauchamp, ...JOURNAL INFO: Journal of breath research 14 (4), 046008YEAR: 2020LINK https://iopscience.iop.org/article/10.1088/1752-7163/aba130/pdf
Real-time breath analysis of exhaled compounds upon peppermint oil ingestion by secondary electrospray ionization-high resolution mass spectrometry: technical aspects
AUTHORS: A Gisler, J Lan, KD Singh, J Usemann, U Frey, R Zenobi, P SinuesJOURNAL INFO: Journal of Breath Research 14 (4), 046001YEAR: 2020LINK https://iopscience.iop.org/article/10.1088/1752-7163/ab9f8b/pdf
Real-time breath analysis reveals specific metabolic signatures of COPD exacerbations
AUTHORS: MT Gaugg, Y Nussbaumer-Ochsner, L Bregy, A Engler, N Stebler, T Gaisl, ...JOURNAL INFO: Chest 156 (2), 269-276YEAR: 2019LINK https://www.sciencedirect.com/science/article/pii/S0012369219300625
Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry
AUTHORS: KD Singh, G Tancev, F Decrue, J Usemann, R Appenzeller, P Barreiro, ...JOURNAL INFO: Analytical and bioanalytical chemistry 411 (19), 4883-4898YEAR: 2019LINK https://link.springer.com/article/10.1007/s00216-019-01764-8
Real-time breath analysis of antiepileptic drugs
AUTHORS: KD Singh, V Ziesenitz, J Usemann, U Frey, J van den Anker, A Datta, ...JOURNAL INFO: Archives of Disease in Childhood 104 (6), e55-e55YEAR: 2019LINK https://adc.bmj.com/content/archdischild/104/6/e55.1.full.pdf
Progress towards Therapeutic Drug Monitoring via breath analysis
AUTHORS: KD Singh, V Ziesenitz, J Usemann, J Van Den Anker, U Frey, ...JOURNAL INFO: Archives of Disease in Childhood 104 (6), e9-e9YEAR: 2019LINK https://adc.bmj.com/content/archdischild/104/6/e9.2.full.pdf
Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis
AUTHORS: MT Gaugg, A Engler, L Bregy, Y Nussbaumer‐Ochsner, L Eiffert, ...JOURNAL INFO: Respirology 24 (5), 437-444YEAR: 2019LINK https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/resp.13465
Real-time monitoring of tricarboxylic acid metabolites in exhaled breath
AUTHORS: A Tejero Rioseras, KD Singh, N Nowak, MT Gaugg, T Bruderer, R Zenobi, ...JOURNAL INFO: Analytical chemistry 90 (11), 6453-6460YEAR: 2018LINK https://pubs.acs.org/doi/full/10.1021/acs.analchem.7b04600
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