Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Prof. Dr. Pablo Sinues Ph.D.
Head of Translational Medicine Research Group
Mélina Richard
Lead Research Coordinator, Research Associate
+41 61 704 14 11
PROJECTS
> Placebolomics; Breath Metabolomics of Placebo Effects
> Breath Metabolomics of Pain and Stress
Jiafa Zeng
PhD Candidate
PROJECTS
Mo Awchi
PhD Candidate
PROJECTS
Zhihong Yin
PhD Candidate
PROJECTS
Noemi Künstle
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow
Former Group Members
Amanda Gisler, PhD
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System
Kim Fabienne Arnold, PhD
Translating secondary electrospray ionization–high-resolution mass spectrometry to the clinical environment
AUTHORS: KD Singh, GV Del Miguel, MT Gaugg, AJ Ibañez, R Zenobi, M Kohler, ...JOURNAL INFO: Journal of breath research 12 (2), 027113YEAR: 2018LINK https://iopscience.iop.org/article/10.1088/1752-7163/aa9ee3/pdf
Real-time mass spectrometric identification of metabolites characteristic of chronic obstructive pulmonary disease in exhaled breath
AUTHORS: L Bregy, Y Nussbaumer-Ochsner, PML Sinues, D García-Gómez, Y Suter, ...JOURNAL INFO: Clinical Mass Spectrometry 7, 29-35YEAR: 2018LINK https://www.sciencedirect.com/science/article/pii/S2376999817300405
Rapid fingerprinting of grape volatile composition using secondary electrospray ionization orbitrap mass spectrometry: A preliminary study of grape ripening
AUTHORS: RR Farrell, J Fahrentrapp, D García-Gómez, PML Sinues, R ZenobiJOURNAL INFO: Food Control 81, 107-112YEAR: 2017LINK https://www.sciencedirect.com/science/article/pii/S0956713517302037
Comprehensive real-time analysis of the yeast Volatilome
AUTHORS: AT Rioseras, DG Gomez, BE Ebert, LM Blank, AJ Ibáñez, PML SinuesJOURNAL INFO: Scientific reports 7 (1), 1-9YEAR: 2017LINK https://www.nature.com/articles/s41598-017-14554-y
Mass-spectrometric detection of omega-oxidation products of aliphatic fatty acids in exhaled breath
AUTHORS: MT Gaugg, T Bruderer, N Nowak, L Eiffert, P Martinez-Lozano Sinues, ...JOURNAL INFO: Analytical chemistry 89 (19), 10329-10334YEAR: 2017LINK https://pubs.acs.org/doi/full/10.1021/acs.analchem.7b02092
Metabolic effects of inhaled salbutamol determined by exhaled breath analysis
AUTHORS: MT Gaugg, A Engler, Y Nussbaumer-Ochsner, L Bregy, AS Stöberl, ...JOURNAL INFO: Journal of breath research 11 (4), 046004YEAR: 2017LINK https://iopscience.iop.org/article/10.1088/1752-7163/aa7caa/pdf
Real-time exhaled breath analysis identifies altered metabolic signature in cystic fibrosis
AUTHORS: T Gaisl, L Bregy, N Stebler, M Gaugg, T Bruderer, D García-Gómez, ...JOURNAL INFO: Chest 151 (5), A104YEAR: 2017LINK https://www.sciencedirect.com/science/article/pii/S0012369217306530?via%3Dihub
Targeted on-line breath analysis discriminates COPD patients vs. healthy controls and subjects suffering from asthma
AUTHORS: Y Nussbaumer-Ochsner, MT Gaugg, L Bregy, A Engler, SA Sophie, ...JOURNAL INFO: Chest 151 (5), A46-A47YEAR: 2017LINK https://www.sciencedirect.com/science/article/pii/S0012369217305937?via%3Dihub
on-line breath analysis with secondary electrospray ionization discriminates between COPD patients with and without frequent exacerbations
AUTHORS: MT Gaugg, Y Nussbaumer-Ochsner, L Bregy, A Engler, N Stebler, ...JOURNAL INFO: Chest 151 (5), A5YEAR: 2017LINK https://www.sciencedirect.com/science/article/pii/S0012369217305494?via%3Dihub
Exhaled breath analysis by real-time mass spectrometry in patients with pulmonary fibrosis
AUTHORS: P Sinues, Y Nussbaumer-Ochsner, MT Gaugg, L Bregy, A Engler, ...JOURNAL INFO: Chest 151 (5), A16YEAR: 2017LINK https://www.sciencedirect.com/science/article/pii/S0012369217305603?via%3Dihub
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