Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Core Members
Group Members
Zhihong Yin
PhD Candidate
Former Group Members
Dr. Nachelli Malpica
Former Master Student
PROJECTS
> Development of Standard Operating Procedures for Reproducible Offline Breath Analysis
Dr. Malena Maira Gwerder, MD
Former PhD Candidate
PROJECTS
> Bern Basel Infant Lung Development (BILD) cohort
NEXT
> Assistant Pediatric Doctor at UKBB
Dr. Mo Awchi
Former PhD Candidate
PROJECTS
> Therapeutic Drug Monitoring Guided by Breath Analysis
NEXT
> Senior Operational Specialist at Lonza
Isabel Gonzalez
Former Lead Study Nurse
Dr. Diego Manuel Baur
Former Postdoctoral Researcher
Moor de Waal
Former Student Assistant
Dr. Amanda Gisler
Former PhD Student
PROJECTS
> Standardizing Real-Time Breath Analysis
> Impact of Air Pollution on the Respiratory System
NEXT
> Management Board Member, LUSTAT Statistics
Fabienne Decrue
Former Responsible Pediatric Doctor
PROJECTS
> Standardisation of Mass Spectrometer Offline Sampling
NEXT
> Pediatric Doctor at UKBB
Dr. Noemi Künstle, MD
Former PhD Candidate
PROJECTS
> Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
Dr. Jiafa Zeng
Former PhD Candidate
Dr. Kim Fabienne Arnold
Former PhD Student
Circadian Metabolomics from Breath
AUTHORS: SA Brown, P SinuesJOURNAL INFO: Circadian Clocks, 149-156YEAR: 2021LINK https://link.springer.com/protocol/10.1007%2F978-1-0716-0381-9_11
A benchmarking protocol for breath analysis: the peppermint experiment
AUTHORS: B Henderson, DM Ruszkiewicz, M Wilkinson, JD Beauchamp, ...JOURNAL INFO: Journal of breath research 14 (4), 046008YEAR: 2020LINK https://iopscience.iop.org/article/10.1088/1752-7163/aba130/pdf
Real-time breath analysis of exhaled compounds upon peppermint oil ingestion by secondary electrospray ionization-high resolution mass spectrometry: technical aspects
AUTHORS: A Gisler, J Lan, KD Singh, J Usemann, U Frey, R Zenobi, P SinuesJOURNAL INFO: Journal of Breath Research 14 (4), 046001YEAR: 2020LINK https://iopscience.iop.org/article/10.1088/1752-7163/ab9f8b/pdf
Real-time breath analysis reveals specific metabolic signatures of COPD exacerbations
AUTHORS: MT Gaugg, Y Nussbaumer-Ochsner, L Bregy, A Engler, N Stebler, T Gaisl, ...JOURNAL INFO: Chest 156 (2), 269-276YEAR: 2019LINK https://www.sciencedirect.com/science/article/pii/S0012369219300625
Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry
AUTHORS: KD Singh, G Tancev, F Decrue, J Usemann, R Appenzeller, P Barreiro, ...JOURNAL INFO: Analytical and bioanalytical chemistry 411 (19), 4883-4898YEAR: 2019LINK https://link.springer.com/article/10.1007/s00216-019-01764-8
Real-time breath analysis of antiepileptic drugs
AUTHORS: KD Singh, V Ziesenitz, J Usemann, U Frey, J van den Anker, A Datta, ...JOURNAL INFO: Archives of Disease in Childhood 104 (6), e55-e55YEAR: 2019LINK https://adc.bmj.com/content/archdischild/104/6/e55.1.full.pdf
Progress towards Therapeutic Drug Monitoring via breath analysis
AUTHORS: KD Singh, V Ziesenitz, J Usemann, J Van Den Anker, U Frey, ...JOURNAL INFO: Archives of Disease in Childhood 104 (6), e9-e9YEAR: 2019LINK https://adc.bmj.com/content/archdischild/104/6/e9.2.full.pdf
Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis
AUTHORS: MT Gaugg, A Engler, L Bregy, Y Nussbaumer‐Ochsner, L Eiffert, ...JOURNAL INFO: Respirology 24 (5), 437-444YEAR: 2019LINK https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/resp.13465
Real-time monitoring of tricarboxylic acid metabolites in exhaled breath
AUTHORS: A Tejero Rioseras, KD Singh, N Nowak, MT Gaugg, T Bruderer, R Zenobi, ...JOURNAL INFO: Analytical chemistry 90 (11), 6453-6460YEAR: 2018LINK https://pubs.acs.org/doi/full/10.1021/acs.analchem.7b04600
Real-time exhaled breath analysis in patients with cystic fibrosis and controls
AUTHORS: T Gaisl, L Bregy, N Stebler, MT Gaugg, T Bruderer, D García-Gómez, ...JOURNAL INFO: Journal of breath research 12 (3), 036013YEAR: 2018LINK https://iopscience.iop.org/article/10.1088/1752-7163/aab7fd/pdf
Spin-off company
