Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Prof. Dr. Pablo Sinues Ph.D.
Head of Translational Medicine Research Group
Mélina Richard
Lead Research Coordinator, Research Associate
+41 61 704 14 11
PROJECTS
> Placebolomics; Breath Metabolomics of Placebo Effects
> Breath Metabolomics of Pain and Stress
Jiafa Zeng
PhD Candidate
PROJECTS
Zhihong Yin
PhD Candidate
PROJECTS
Noemi Künstle
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow
Former Group Members
Mo Awchi
PhD Candidate
PROJECTS
Amanda Gisler, PhD
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System
Kim Fabienne Arnold, PhD
Real-time exhaled breath analysis identifies altered metabolic signature in cystic fibrosis
AUTHORS: T Gaisl, L Bregy, N Stebler, M Gaugg, T Bruderer, D García-Gómez, ...JOURNAL INFO: Chest 151 (5), A104YEAR: 2017LINK https://www.sciencedirect.com/science/article/pii/S0012369217306530?via%3Dihub
Targeted on-line breath analysis discriminates COPD patients vs. healthy controls and subjects suffering from asthma
AUTHORS: Y Nussbaumer-Ochsner, MT Gaugg, L Bregy, A Engler, SA Sophie, ...JOURNAL INFO: Chest 151 (5), A46-A47YEAR: 2017LINK https://www.sciencedirect.com/science/article/pii/S0012369217305937?via%3Dihub
on-line breath analysis with secondary electrospray ionization discriminates between COPD patients with and without frequent exacerbations
AUTHORS: MT Gaugg, Y Nussbaumer-Ochsner, L Bregy, A Engler, N Stebler, ...JOURNAL INFO: Chest 151 (5), A5YEAR: 2017LINK https://www.sciencedirect.com/science/article/pii/S0012369217305494?via%3Dihub
Exhaled breath analysis by real-time mass spectrometry in patients with pulmonary fibrosis
AUTHORS: P Sinues, Y Nussbaumer-Ochsner, MT Gaugg, L Bregy, A Engler, ...JOURNAL INFO: Chest 151 (5), A16YEAR: 2017LINK https://www.sciencedirect.com/science/article/pii/S0012369217305603?via%3Dihub
Gauging circadian variation in ketamine metabolism by real-time breath analysis
AUTHORS: PML Sinues, M Kohler, SA Brown, R Zenobi, R DallmannJOURNAL INFO: Chemical Communications 53 (14), 2264-2267YEAR: 2017LINK https://pubs.rsc.org/en/content/articlehtml/2017/cc/c6cc09061c
Secondary electrospray ionization proceeds via gas-phase chemical ionization
AUTHORS: AT Rioseras, MT Gaugg, PML SinuesJOURNAL INFO: Analytical Methods 9 (34), 5052-5057YEAR: 2017LINK https://pubs.rsc.org/en/content/articlehtml/2017/ay/c7ay01121k
Real Time Read-Out of Plant Metabolism
AUTHORS: C Barrios-Collado, D García-Gómez, R Zenobi, G Vidal-de-Miguel, ...JOURNAL INFO: CHIMIA International Journal for Chemistry 70 (9), 660-660YEAR: 2016LINK...
Real-time determination of slightly volatile amino acids in the exhalome by secondary electrospray ionization. A proof-of-principle study
AUTHORS: T Gaisl, D García-Gómez, L Bregy, A Cremonesi, PML Sinues, M Kohler, ...JOURNAL INFO: European Respiratory Journal 48 (suppl 60)YEAR: 2016LINK https://erj.ersjournals.com/content/48/suppl_60/PA3551
Real-time quantification of amino acids in the Exhalome by secondary electrospray ionization–mass spectrometry: a proof-of-principle study
AUTHORS: D García-Gómez, T Gaisl, L Bregy, A Cremonesi, PML Sinues, M Kohler, ...JOURNAL INFO: Clinical chemistry 62 (9), 1230-1237YEAR: 2016LINK https://academic.oup.com/clinchem/article/62/9/1230/5611979
Noninvasive strategies for breast cancer early detection
AUTHORS: G Trecate, PML Sinues, R OrlandiJOURNAL INFO: Future oncology 12 (11), 1395-1411YEAR: 2016LINK https://www.futuremedicine.com/doi/abs/10.2217/fon-2015-0071
Spin-off company
