Translational Research of Today,
Standard Care of Tomorrow


Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine

Generate HYPOTHESIS

design the experiment

measure

analyze

validate
ONGOING PROJECTS

DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.

THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS

DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM

RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members

Prof. Dr. Pablo Sinues Ph.D.
Head of Translational Medicine Research Group


Mélina Richard
Lead Research Coordinator, Research Associate

Kim Fabienne Arnold
PhD Candidate

Amanda Gisler
PhD Candidate
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System

Jiafa Zeng
PhD Candidate
PROJECTS

Mo Awchi
PhD Candidate
PROJECTS

Noemi Künstle
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function


DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow

Secondary electrospray ionization-mass spectrometry and a novel statistical bioinformatic approach identifies a cancer-related profile in exhaled breath of breast cancer …
AUTHORS: PML Sinues, E Landoni, R Miceli, VF Dibari, M Dugo, R Agresti, ...JOURNAL INFO: Journal of breath research 9 (3), 031001YEAR: 2015LINK https://patentimages.storage.googleapis.com/e5/87/96/105b32cef03209/US9121844.pdf
The effect of CPAP withdrawal on exhaled breath in OSA–A randomised controlled trial
AUTHORS: EI Schwarz, PML Sinues, L Bregy, DG Gomez, T Gaisl, M Gaugg, ...JOURNAL INFO: European Respiratory Journal 46 (suppl 59)YEAR: 2015LINK...
Method to analyze and classify persons and organisms based on odor patterns from released vapors
AUTHORS: PML Sinues, JF De La MoraJOURNAL INFO: US Patent 9,121,844YEAR: 2015LINK https://patentimages.storage.googleapis.com/e5/87/96/105b32cef03209/US9121844.pdf
Drug pharmacokinetics determined by real‐time analysis of mouse breath
AUTHORS: X Li, P Martinez‐Lozano Sinues, R Dallmann, L Bregy, M Hollmén, ...JOURNAL INFO: Angewandte Chemie International Edition 54 (27), 7815-7818YEAR: 2015LINK https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.201503312
Pharmakokinetik von Medikamenten durch Echtzeit‐Analyse der Atemluft von Mäusen
AUTHORS: X Li, P Martinez‐Lozano Sinues, R Dallmann, L Bregy, M Hollmén, ...JOURNAL INFO: Angewandte Chemie 127 (27), 7926-7929YEAR: 2015LINK https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.201503312
The Effect of CPAP Withdrawal on Exhaled Breath in Obstructive Sleep Apnea-A Randomized Controlled Trial: 26
AUTHORS: E Schwarz, ML Sinues, L Bregy, T Gaisl, M Gaugg, ...JOURNAL INFO: Respiration 89 (5), 450-451YEAR: 2015LINK...
Rapid Discrimination betweenStreptococcus Pneumoniaeand OtherStreptococciby Mass Spectrometric Analysis of Volatile Metabolites: P141
AUTHORS: ML Sinues, L Bregy, R Zenobi, R Zbinden, M KohlerJOURNAL INFO: Respiration 89 (5), 491-492YEAR: 2015LINK...
Identification of 2-alkenals, 4-hydroxy-2-alkenals, and 4-hydroxy-2, 6-alkadienals in exhaled breath condensate by UHPLC-HRMS and in breath by real-time HRMS
AUTHORS: D García-Gómez, P Martínez-Lozano Sinues, C Barrios-Collado, ...JOURNAL INFO: Analytical chemistry 87 (5), 3087-3093YEAR: 2015LINK https://pubs.acs.org/doi/pdf/10.1021/ac504796p
Circadian variation of the human metabolome captured by real-time breath analysis
AUTHORS: P Martinez-Lozano Sinues, L Tarokh, X Li, M Kohler, SA Brown, R Zenobi, ...JOURNAL INFO: PloS one 9 (12), e114422YEAR: 2014LINK https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114422
Ion mobility spectrometry coupled to laser-induced fluorescence for probing the electronic structure and conformation of gas-phase ions
AUTHORS: VE Frankevich, KV Barylyuk, PML Sinues, R ZenobiJOURNAL INFO: Journal of Analytical Chemistry 69 (13), 1215-1219YEAR: 2014LINK https://link.springer.com/content/pdf/10.1134/S106193481413005X.pdf
Spin-off company








