Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Call for Abstracts for Metabolomics 2024!
Complete details online: https://www.metabolomics2024.org/abstract-submissions
Deadline for oral abstracts is March 7.
#metabolomics
The Annual Meeting of the Swiss Metabolomics Society on Sep 15 with @ESchymanski @matejoresic @LF_Nothias etc is approaching!
The program is online, registrations still open, and the deadline for posters is closing soon. Hurry up!
Check https://swiss-metabolomics.ch/annual-meeting/.
@swiss_society
You can sniff with an MS on the air of a dendritic cell culture and detect metabolites! I am super happy to see our novel technique published.
This was a great collaboration with Kim Arnold from the @SinuesLab, spearheaded by Pablo and @MariaLBalmer!
Research Group
Members
Prof. Dr. Pablo Sinues Ph.D.
Head of Translational Medicine Research Group
Mélina Richard
Lead Research Coordinator, Research Associate
+41 61 704 14 11
PROJECTS
> Placebolomics; Breath Metabolomics of Placebo Effects
> Breath Metabolomics of Pain and Stress
Jiafa Zeng
PhD Candidate
PROJECTS
Zhihong Yin
PhD Candidate
PROJECTS
Noemi Künstle
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow
Moor de Waal
Administrative Assistant
Former Group Members
Mo Awchi
PhD Candidate
PROJECTS
Amanda Gisler, PhD
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System
Kim Fabienne Arnold, PhD
Secondary electrospray ionization coupled to high-resolution mass spectrometry reveals tryptophan pathway metabolites in exhaled human breath
AUTHORS: D García-Gómez, T Gaisl, L Bregy, PML Sinues, M Kohler, R ZenobiJOURNAL INFO: Chemical Communications 52 (55), 8526-8528YEAR: 2016LINK https://iopscience.iop.org/article/10.1088/1752-7155/9/3/031001/pdf
Differentiation of oral bacteria in in vitro cultures and human saliva by secondary electrospray ionization–mass spectrometry
AUTHORS: L Bregy, AR Müggler, PML Sinues, D García-Gómez, Y Suter, ...JOURNAL INFO: Scientific reports 5 (1), 1-10YEAR: 2015LINK https://erj.ersjournals.com/content/46/suppl_59/OA1749
Secondary electrospray ionization-mass spectrometry and a novel statistical bioinformatic approach identifies a cancer-related profile in exhaled breath of breast cancer …
AUTHORS: PML Sinues, E Landoni, R Miceli, VF Dibari, M Dugo, R Agresti, ...JOURNAL INFO: Journal of breath research 9 (3), 031001YEAR: 2015LINK https://patentimages.storage.googleapis.com/e5/87/96/105b32cef03209/US9121844.pdf
The effect of CPAP withdrawal on exhaled breath in OSA–A randomised controlled trial
AUTHORS: EI Schwarz, PML Sinues, L Bregy, DG Gomez, T Gaisl, M Gaugg, ...JOURNAL INFO: European Respiratory Journal 46 (suppl 59)YEAR: 2015LINK...
Method to analyze and classify persons and organisms based on odor patterns from released vapors
AUTHORS: PML Sinues, JF De La MoraJOURNAL INFO: US Patent 9,121,844YEAR: 2015LINK https://patentimages.storage.googleapis.com/e5/87/96/105b32cef03209/US9121844.pdf
Drug pharmacokinetics determined by real‐time analysis of mouse breath
AUTHORS: X Li, P Martinez‐Lozano Sinues, R Dallmann, L Bregy, M Hollmén, ...JOURNAL INFO: Angewandte Chemie International Edition 54 (27), 7815-7818YEAR: 2015LINK https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.201503312
Pharmakokinetik von Medikamenten durch Echtzeit‐Analyse der Atemluft von Mäusen
AUTHORS: X Li, P Martinez‐Lozano Sinues, R Dallmann, L Bregy, M Hollmén, ...JOURNAL INFO: Angewandte Chemie 127 (27), 7926-7929YEAR: 2015LINK https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.201503312
The Effect of CPAP Withdrawal on Exhaled Breath in Obstructive Sleep Apnea-A Randomized Controlled Trial: 26
AUTHORS: E Schwarz, ML Sinues, L Bregy, T Gaisl, M Gaugg, ...JOURNAL INFO: Respiration 89 (5), 450-451YEAR: 2015LINK...
Rapid Discrimination betweenStreptococcus Pneumoniaeand OtherStreptococciby Mass Spectrometric Analysis of Volatile Metabolites: P141
AUTHORS: ML Sinues, L Bregy, R Zenobi, R Zbinden, M KohlerJOURNAL INFO: Respiration 89 (5), 491-492YEAR: 2015LINK...
Identification of 2-alkenals, 4-hydroxy-2-alkenals, and 4-hydroxy-2, 6-alkadienals in exhaled breath condensate by UHPLC-HRMS and in breath by real-time HRMS
AUTHORS: D García-Gómez, P Martínez-Lozano Sinues, C Barrios-Collado, ...JOURNAL INFO: Analytical chemistry 87 (5), 3087-3093YEAR: 2015LINK https://pubs.acs.org/doi/pdf/10.1021/ac504796p
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