Welcome to the SinuesLab

Translational Research of Today,
Standard Care of Tomorrow

RESEARCH

Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine

Generate HYPOTHESIS

Our interdisciplinary team work coordinately to generate working hypotheses to address our clinical questions

design the experiment

Together with our clinical colleagues we design the right experiment to answer our research questions

measure

We use state-of-the-art high resolution-mass spectrometry to map the exhaled metabolome of our patients

analyze

We use sophisticated bioinformatic tools to decode complex datasets.

validate

Our results are further validated and generate further hypotheses to advance answering our research questions.

ONGOING PROJECTS

DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS

In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.

THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS

The objective in this project is to optimize the therapeutic regimen of pediatric patients to maximize efficacy and minimize side effects.

DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM

In this project we combine air pollution models, state-of-the-art lung function tests and our breath metabolomics approach to better understand the detrimental effects of air pollution exposure in children.

RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS

Our objective is to diagnose infectious diseases, with a focus on pneumonia, by combining our high resolution/high mass accuracy real-time breath analysis technology combined with Artificial Intelligence to provide a positive/negative response within 15 minutes.

News

Sinues Lab

SinuesLab

At the very cool venue of , Mélina of our group attended the International Conference of the S....

At the very cool venue of @Landschaftspark, Mélina of our group attended the International Conference of the Society for Interdisciplinary Placebo Studies #SIPSplacebo and presented her Placebolomics... 3 Likes 1 Retweets

Liron Rozenkrantz

LironRozenkrant

Thank you Melina and Pablo @SinuesLab @UniBasel_en for inviting me to present our research at your Placebo Effects special seminar series!
I had a wonderful time and Basel is gorgeous, can't wait to... 2 Retweets

Sinues Lab

SinuesLab

Our seminar series: 'Quantifying Placebo Effects: Problems and Limitations' has kicked off and our first invited speaker @dmellingsen talked about brain-behavioral mechanisms of placebo effects. The s... 2 Likes

Journal of Proteome Research

JProteomeRes

🔓 #OpenAccess: "UHPLC-MS/MS-Based Identity Confirmation of Amino Acids Involved in Response to and Side Effects from Antiseizure Medications"
https://t.co/zZh4Y3sN9q 1 Retweets

Sinues Lab

SinuesLab

Metabolite confirmation is a bottleneck in large metabolomics studies. Here we present the confirmation of 6 Amino acids in breath which were previously reported to be involved in response to and side... 3 Likes

Martin Röösli

MartinRoosli

🆕Ambient prenatal air pollution exposure is associated with low cord blood IL‐17a in infants https://t.co/mEp7vN0Rqx
@gisler_amanda @DaniVienneau @SinuesLab 1 Retweets

Sinues Lab

SinuesLab

Our and we are ready for the holidays! We wish you a good festive season and a prosperous 2023!🥳🥂

Our #MassSpec and we are ready for the holidays! We wish you a good festive season and a prosperous 2023!🥳🥂 https://t.co/YtPEPrSfKL 14 Likes

Sinues Lab

SinuesLab

In our recent publication in @iScience_CP,
@gisler_amanda and Kapil D. Singh et al. present an interoperability framework for multicenter studies using breath analysis with SESI-HRMS and provide an o... 6 Likes 2 Retweets

Sinues Lab

SinuesLab

Christmas dinner with the team! Cheers🥂 https://t.co/Flb1w1WkmK 10 Likes

Sinues Lab

SinuesLab

A former lab member of ours, @fabienne_decrue, was awarded the prize for the best dissertation in the faculty of medicine during Dies Academicus of @UniBasel_en. Congratulations Fabienne, we are very... 10 Likes

Sinues Lab

SinuesLab

Greetings from the Minions! Interesting industrial visit looking into stent coating processes in the clean room of #Biotronik AG, made possible by the Swiss Society for Biomedical Engineering #SSBE. @... 5 Likes

RAICEX

raicex_es

Hoy hemos abordado en #PuntoEnlace de @ree_rne el I Encuentro de @comunidadASIERI @SIEF_SCEF y @aso_acech en @CERN con @SinuesLab y con José Miguel Jiménez, jefe de tecnología en #CERN . Nos os lo per... 2 Retweets

Sinues Lab

SinuesLab

New team members, new academic year, new group photo!🖼️ https://t.co/n2PEzIST1g 8 Likes

Sinues Lab

SinuesLab

We were present at the university children's hospital Basel research day. Showcasing our studie....

We were present at the university children's hospital Basel research day. Showcasing our #breathanalysis studies. 🫁 https://t.co/SK0qeU3tMj 4 Likes

Sinues Lab

SinuesLab

We have a new lab member! Zhihong Yin previously worked on in vivo diagnosis of influenza A with SESI-HRMS and is going to continue with metabolic monitoring of diseases with SESI-HRMS! Good luck Zhih... 1 Likes

Sinues Lab

SinuesLab

Two of our group members were picked to proudly present two of our projects at the 39th swiss group for mass spectrometry meeting in beautiful beatenberg. #sgms #Metabolomics https://t.co/dE8QGwWDdi 10 Likes 2 Retweets

Swiss Metabolomics Society

swiss_society

Metabolomics at the 39th SG-MS in Beatenberg: „Placebolomics:Breath metabolomics of placebo effects“ as the fitst student talk today. Very well presented by Mélina Richard from @SinuesLab https://t.c... 2 Retweets

Julijana Ivanisevic

JuliJivanisevic

Great team from @SinuesLab and innovative work with high translational potential! REAL-TIME #breath analysis. Don't miss to visit their website https://t.co/Ler0BYw8qV with beatifuly illustrated appli... 1 Retweets

Sinues Lab

SinuesLab

An interesting and good _society meeting last week in Lausanne. A selfie with (almost) all the l....

An interesting and good @swiss_society meeting last week in Lausanne. A selfie with (almost) all the lab members had to be taken🤳 https://t.co/pR8OXJrXYt 8 Likes 3 Retweets

Zinkernagel Lab Zurich

AZinkernagelLab

Great collaboration with @SinuesLab! We developed a method for "Rapid detection of Staphylococcus aureus and Streptococcus pneumoniae by real-time analysis of volatile metabolites" and tested it on so... 7 Retweets

sdb-lab.org

sdb_lab

Rapid detection of Staphylococcus aureus and Streptococcus pneumoniae by real-time analysis of volatile metabolites! congrats to @Alejogo021 @AZinkernagelLab @SinuesLab https://t.co/GAybpCQKTM 4 Retweets

Sinues Lab

SinuesLab

Recently, one of our lab members, _amanda, graduated summa cum laude with her Ph.D. thesis title....

Recently, one of our lab members, @gisler_amanda, graduated summa cum laude with her Ph.D. thesis titled: Main and Interaction Effects of Gaseous and Particulate Pollutants on Respiratory Health in Ch... 7 Likes

Sinues Lab

SinuesLab

Yesterday we had our 8th departmental research day and a cool interactive talk from @Kimfabiasci!🥳🧐 https://t.co/VVtKHaoU9j 6 Likes

Sinues Lab

SinuesLab

A publication of ours from 2013: https://t.co/xWlsBmhG3o was recently added to PLOS ONEs curated collection of pioneering research in the field of Peronalized Medicine! 4 Likes

Sinues Lab

SinuesLab

Our latest paper by @Kimfabiasci et al. shows that in vivo detection of metabolic deuterium incorporation upon ingestion of deuterated water is possible by SESI-HRMS. Opening new doors for in vivo met... 10 Likes 1 Retweets

Julijana Ivanisevic

JuliJivanisevic

Thanks to @MetabolomicsSoc board and the entire #metabolomics community for making 2022 event in Valencia so memorable. Great science and lots of fun. And an amazingly well represented @swiss_society... 13 Retweets

Martin Röösli

MartinRoosli

New findings from the BILD cohort indicate that preterm infants are more susceptibility to prenatal #AirPollution exposure than term infants, leading to increased impairment of postnatal lung function... 3 Retweets

Raquel

Raquel_Rouco

Finally out! If you want to know more about how a single enhancer loss produces cell-specific alterations eventually leading to clubfoot phenotype don't miss the revised version of our story in @Natur... 2 Retweets

Jasper Boeddinghaus

J_Boeddinghaus

Extremely proud of my wife Fabienne Decrue who has finished her MD-PhD @ukbbkinderspit1 @SinuesLab @SwissTPH with highest praise while being a caring mom and pregnant with our 2nd child. Latest: @ATSB... 1 Retweets

Sinues Lab

SinuesLab

@HGallartAyala Thank you Hector! It was great discussing science face-to-face with you.

Sinues Lab

SinuesLab

@swiss_society Big thank you to the entire #Metabolomics and #MassSpec communities. It has been such an honor. 1 Likes 1 Retweets

Sinues Lab

SinuesLab

Is it feasible to measure #breath from patients, incapable of performing exhalation maneuvers, including infants, for #metabolomic purposes? Our latest publication in @an_chem, provides a perspective... 4 Likes 2 Retweets

The Nobel Prize

NobelPrize

BREAKING NEWS:
The 2021 #NobelPrize in Physiology or Medicine has been awarded jointly to David Julius and Ardem Patapoutian “for their discoveries of receptors for temperature and touch.” https://t.... 10.2K Retweets

Swiss Business Hub

SBH_USA

And the winner is… Switzerland! Our country has led the ranking of the Global Innovation Index since 2011 steadily and continues to top the table. #GII2018 https://t.co/nBFZbfRlzf https://t.co/zsSVXs0... 2 Retweets

Sinues Lab

SinuesLab

We are celebrating 50 years since double Nobel Leareate Linus Pauling et al. published their landmark PNAS paper on the detection of metabolites in human breath. The inspiring piece of work uncapped a... 3 Likes

Sinues Lab

SinuesLab

A succesful day at the _Unibasel research day, presenting our posters and having an inspiring ta....

A succesful day at the @DBE_Unibasel research day, presenting our posters and having an inspiring talk! 🫁 https://t.co/6WQExwMz9m 5 Likes

CSIC Divulga

CSICdivulga

26/08/1743. #UnDíaComoHoy nacía en París Antoine Lavoisier, precursor de la química moderna. Descubre los principales hitos y aplicaciones de esta disciplina con 'Entre Moléculas', una de las #exposic... 33 Retweets

Deep Breath Intelligence

the_dbi

Good and impressive news are spreading globally.
Regarding the recent publication in communication medicine on Personalised therapeutic management for epileptic patients, here an article from indi... 3 Retweets

Communications Medicine

CommsMedicine

Singh et al. perform a breath #metabolomics study in patients with #epilepsy taking antiseizure medications, with breath analysis enabling prediction of systemic drug concentrations, drug response &am... 3 Retweets

Sinues Lab

SinuesLab

We are happy to share this educational video
explaining our #research at @ukbbkinderspit1 @DBE_Unibasel @UniBasel_en
on #BreathAnalysis #Metabolomics, published with @SpringerNature in @CommsMedicin... 5 Likes 4 Retweets

Sinues Lab

SinuesLab

Can you perform pharmacokinetic studies via #breathanalysis? A collaboration review with the SinuesLab and colleagues at @usal put the advances in this domain in perspective. https://t.co/KHrztBG1Wv 2 Likes

Swiss Metabolomics Society

swiss_society

The next Swiss Metabolomics Society & Partners online seminar will be on August 30, 2021 I 12:00-13:00 Prof. Gérard Hopfgartner, University of Geneva will present. Just checkout our homepage https... 4 Retweets

Sinues Lab

SinuesLab

Our latest paper on breath #metabolomics and #epilepsy was highlighted in a news article from @UniBasel_en. A little insight into the work behind the publication!
Breath test to determine correct... 3 Likes

Communications Medicine

CommsMedicine

💡 NEW RESEARCH! Singh et al. perform a breath #metabolomics study in patients with #epilepsy taking antiseizure medications, with breath analysis enabling prediction of systemic drug concentrations, d... 6 Retweets

Sinues Lab

SinuesLab

We are delighted to share our latest #research at @ukbbkinderspit1 @DBE_Unibasel @UniBasel_en on #BreathAnalysis #Metabolomics #epilepsy, published with @SpringerNature in @CommsMedicine https://t.co/... 7 Likes 1 Retweets

Deep Breath Intelligence

the_dbi

DBI`s CEO, Christian Zwicky was interviewed for Tagesschau at SRF (Schweizer Radio und Fernsehen) about our breath technology and analysis for Covid19 and other diseases.
Check out the broadcast!
... 1 Retweets

Swiss Metabolomics Society

swiss_society

Don't forget to join our next Swiss Metabolomics Society & Partners online seminar tomorrow (12:00 – 13:00). It is directly accessible via link on our homepage (without registration) https://t.co/... 2 Retweets

Gary Siuzdak

kadzuis

All you need to know in one figure. Juliana Ivanisevic @unil & @MartinGiera depict why metabolites are at the center of our biochemical universe https://t.co/kflmnBMzYf. Metabolites are the glue t... 105 Retweets

Communications Medicine

CommsMedicine

Our first articles are now live! Read the @CommsMedicine editorial published today: https://t.co/WksKfKyWPS https://t.co/2vWUM8H9dX 27 Retweets

RAICEX

raicex_es

¡Estamos de estreno 📣 ! Ya podéis acceder a nuestra web https://t.co/9AKl4aTyPO Ahí podréis encontrar información como:
🌍 Asociaciones miembro
👥 Equipo y organización
👉 Suscripción newslet... 14 Retweets

ABOUT US

Research Group
Members

Prof. Dr. Pablo Sinues Ph.D.

Head of Translational Medicine Research Group

pablo.sinues@ukbb.ch

+41 617 042 949

Dr. Kapil Dev Singh Ph.D.

Senior Scientist

kapil.singh@ukbb.ch

+41 61 704 29 48

Mélina Richard

Lead Research Coordinator, Research Associate

melina.richard@ukbb.ch

+41 61 704 14 11

PROJECTS

> Placebolomics; Breath Metabolomics of Placebo Effects

> Breath Metabolomics of Pain and Stress

Amanda Gisler

Postdoc

amanda.gisler@ukbb.ch

+41 61 704 27 84

PROJECTS

> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis

Isabel Gonzalez

Lead Study Nurse

isabel.gonzalez@ukbb.ch

+41 61 704 29 43

+41 61 704 29 42

Mana Okada Thommen

Study Nurse BILD, EBECA

mana.okada@ukbb.ch

+41 61 704 10 41

PUBLICATIONS

a Nano-Dma with no Voltage Change Between Inlet and Outlet

2004

AUTHORS: P Martínez-Lozano, M Labowsky, JF de La MoraJOURNAL INFO: Journal of Aerosol Science 35, S751-S752YEAR: 2004LINK https://www.sciencedirect.com/science/article/pii/S0021850219301284?via%3Dihub

Experimental validation of a high resolution nano-DMA

2004

AUTHORS: E Ramiro, M Sánchez, F Ramiro, J Fernández De La Mora, ...JOURNAL INFO: Journal of Aerosol Science 35, 749-758YEAR: 2004LINK https://www.sciencedirect.com/science/article/pii/S0021850204001144?via%3Dihub

SPINOFF

Spin-off company

Deep Breath Intelligence A.G. is a spin-off company of the University of Basel co-founded by Prof. Pablo Sinues.

DBI’s vision is to uncover the full potential of Molecular Breath Analysis to advance precision medicine and make it available for general health care.