Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Jiafa Zeng
PhD Candidate
Zhihong Yin
PhD Candidate
Noemi Künstle
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow
Diego Manuel Baur
Postdoc
Former Group Members
Amanda Gisler, PhD
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System
Kim Fabienne Arnold, PhD
Pharmacometabolomics via real-time breath analysis captures metabotypes of asthmatic children associated with salbutamol responsiveness
AUTHORS: Jiafa Zeng, Jakob Usemann, Kapil Dev Singh, Anja Jochmann, Daniel Trachsel, Urs Frey, Pablo Sinues JOURNAL INFO: iScience, 2024, 111446, ISSN 2589-0042 YEAR: 2024 LINK: https://doi.org/10.1016/j.isci.2024.111446
Differences in autophagy marker levels at birth in preterm vs. term infants
AUTHORS: Noëmi Künstle, Olga Gorlanova, Andrea Marten, Loretta Müller, Pawan Sharma, Martin Röösli, Pablo Sinues, Primo Schär, David Schürmann, Céline Rüttimann, Carla Rebeca Da Silva Sena, Uri Nahum, Jakob Usemann, Ruth Steinberg, Sophie Yammine, Sven Schulzke,...
Metabolic trajectories of diabetic ketoacidosis onset described by breath analysis
AUTHORS: Mo Awchi, Kapil Dev Singh, Sara Bachmann Brenner, Marie-Anne Burckhardt, Melanie Hess, Jiafa Zeng, Alexandre N. Datta, Urs Frey, Urs Zumsteg, Gabor Szinnai, Pablo Sinues JOURNAL INFO: Frontiers in Endocrinology. 2024, vol. 15 YEAR: 2024 LINK:...
Preservation of exhaled breath samples for analysis by off-line SESI-HRMS: proof-of-concept study
AUTHORS: Rosa A Sola-Martínez, Jiafa Zeng, Mo Awchi, Amanda Gisler, Kim Arnold, Kapil Dev Singh, Urs Frey, Manuel Cánovas Díaz, Teresa de Diego Puente, Pablo Sinues JOURNAL INFO: Journal of Breath Research. 2023, 18.1: 011002 YEAR: 2023 LINK:...
Real-Time Volatile Metabolomics Analysis of Dendritic Cells
AUTHORS: Kim Arnold, Philippe Dehio, Jonas Lötscher, Kapil Dev Singh, Diego García-Gómez, Christoph Hess, Pablo Sinues*, and Maria L. Balmer* JOURNAL INFO: Anal. Chem. 2023, 95, 25, 9415–9421 YEAR: 2023 LINK:...
Late Breaking Abstract – Prenatal exposure to air pollution affects newborns’ autophagy, senescence and remodelling proteins
AUTHORS: Olga Gorlanova, Heide Oller, Uri Nahum, Noemi Künstle, Loretta Müller, Andrea Marten, Céline Rüttimann, Danielle Vienneau, Kees De Hoogh, David Schürmann, Carla Rebeca Da Silva Sena, Martin Röösli, Pablo Sinues, Sven Schulzke, Ruth Steinberg, Jakob Usemann,...
Late Breaking Abstract – Differences in autophagy marker levels at birth in preterm vs. term infants
AUTHORS: Noëmi Künstle, Olga Gorlanova, Andrea Marten, Loretta Müller, Pawan Sharma, Martin Röösli, Pablo Sinues, David Schürmann, Céline Rüttimann, Carla Rebeca Da Silva Sena, Uri Nahum, Jakob Usemann, Ruth Steinberg, Sophie Yammine, Sven Schulzke, Philipp Latzin,...
Prediction of systemic free and total valproic acid by off-line analysis of exhaled breath in epileptic children and adolescents
AUTHORS: Mo Awchi, Kapil Dev Singh, Patricia E Dill, Urs Frey, Alexandre N Datta, Pablo Sinues JOURNAL INFO: J. Breath Res. 17 046013 YEAR: 2023 LINK: https://doi.org/10.1088/1752-7163/acf782
Breath-based therapeutic drug monitoring method
AUTHORS: Kapil Dev Singh, Amanda Gisler, Martin Osswald, Malcolm Kohler, Johannes Van Den Anker, Nicolas Von Der Weid, Urs Frey, Alexandre Datta, Pablo Sinues YEAR: 2023 LINK: https://patents.google.com/patent/US20230277125A1/en
Metabolic trajectories during treatment of diabetic ketoacidosis described by breath analysis
AUTHORS: Mo Awchi, Kapil Dev Singh, Sara Bachmann-Brenner, Marie-Anne Burckhardt, Melanie Hess, Urs Zumsteg, Jiafa Zeng, Alexandre N Datta, Urs Frey, Gabor Szinnai, Pablo Sinues JOURNAL INFO: Hormone Research in Paediatrics. 2023, 96, 180-180. YEAR: 2023 LINK:...
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