Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Core Members
Group Members
Zhihong Yin
PhD Candidate
Former Group Members
Dr. Nachelli Malpica
Former Master Student
PROJECTS
> Development of Standard Operating Procedures for Reproducible Offline Breath Analysis
Dr. Malena Maira Gwerder, MD
Former PhD Candidate
PROJECTS
> Bern Basel Infant Lung Development (BILD) cohort
NEXT
> Assistant Pediatric Doctor at UKBB
Dr. Mo Awchi
Former PhD Candidate
PROJECTS
> Therapeutic Drug Monitoring Guided by Breath Analysis
NEXT
> Senior Operational Specialist at Lonza
Isabel Gonzalez
Former Lead Study Nurse
Dr. Diego Manuel Baur
Former Postdoctoral Researcher
Moor de Waal
Former Student Assistant
Dr. Amanda Gisler
Former PhD Student
PROJECTS
> Standardizing Real-Time Breath AnalysisÂ
> Impact of Air Pollution on the Respiratory System
NEXT
> Management Board Member, LUSTAT Statistics
Fabienne Decrue
Former Responsible Pediatric Doctor
PROJECTS
> Standardisation of Mass Spectrometer Offline Sampling
NEXT
> Pediatric Doctor at UKBB
Dr. Noemi Künstle, MD
Former PhD Candidate
PROJECTS
> Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
Dr. Jiafa Zeng
Former PhD Candidate
Dr. Kim Fabienne Arnold
Former PhD Student
In Vivo Real-Time Metabolic Isotopic Tracing via Breath Analysis upon Deuterated Water Ingestion: A Proof-of-Concept Study
AUTHORS: Zhihong Yin, Kapil Dev Singh, Zhifeng Tang, Mélina Richard, Jiafa Zeng, Urs Frey, Pablo Sinues & Xue Li JOURNAL INFO: ACS Publications YEAR: 2026 https://doi.org/10.1021/acscentsci.6c00078
Cold induced pain elicits reproducible breath metabolomic responses across geographically distinct populations
AUTHORS: Mélina Richard, Kapil Dev Singh, Dilan Sezer, Sarah Buergler, Luana Palermo, Yannick Schulz, Zhifeng Tang, Xin Luo, Urs Frey, Phillipe C. Cattin, Xue Li, Jens Gaab & Pablo Sinues JOURNAL INFO: CellPress YEAR: 2026...
Association of proteins involved in fetal lung development with respiratory outcomes in infancy
AUTHORS: Noëmi Künstle, Olga Gorlanova, Carla Rebeca Da Silva Sena, Florian Wyler, Andrea Marten, Loretta Müller, Céline Rüttimann, Malena Gwerder, Ruth Steinberg, Pawan Sharma, Martin Röösli, Pablo Sinues, Benjamin Stöcklin, Jakob Usemann, Primo Schär, David...
Real-time breath metabolomics as catalyst for personalized lung cancer diagnostics: prospective matched case-control trial (LUCAbreath)
AUTHORS: Felix Schmidt, Diego M. Baur, Patrick Baumgartner, Jonas Herth, Kai Fricke, Noriane A. Sievi, Kapil Dev Singh, Thoma Gaisl, Alice Huang, Daniel Franzen, Silvia Ulrich, Pablo Sinues & Malcom Kohler JOURNAL INFO: Translational Lung Cancer Research YEAR:...
Breath-based Propofol Pharmacometabolomics: Reply
AUTHORS: Jiafa Zeng, Nikola Stankovic, Kapil Dev Singh, Regula Steiner, Urs Frey, Thomas Erb & Pablo Sinues JOURNAL INFO: Anesthesiology YEAR: 2026 https://doi.org/10.1097/ALN.0000000000005866
Late Breaking Abstract – Comparison of lung function, persistent inflammation, and impaired oxidative stress response in preterm and term infants
AUTHORS: Maria Giulia Conti, Diego Baur, Fabienne Decrue, Malena Gwerder, Olga Gorlanova, Carla Rebeca Da Silva Sena, Noëmi Künstle, Benjamin Stöcklin, Sven Schulzke, Jakob Usemann, Philipp Latzin, Urs Frey & Pablo Sinues JOURNAL INFO: European Respiratory (ERS)...
Real-time breath drug metabolic monitoring under stellate ganglion block with lidocaine: a proof-of-concept study
AUTHORS: Zhihong Yin, Wei Xiong, Keda Zhang, Xin Luo, Ming Wei, Kapil Dev Singh, Urs Frey, Xue Li, Xia Feng &Â Pablo Sinues JOURNAL INFO: Discover Medicine YEAR: 2025 https://doi.org/10.1007/s44337-025-00498-0
Reminiscence on Renato Zenobi by Pablo Sinues
AUTHORS: Pablo Sinues JOURNAL INFO: MassSpectrometryReviews YEAR: 2025 https://doi.org/10.1002/mas.70008
Markers in Infants of Mothers With Asthma and Associations With Respiratory Outcomes
AUTHORS: Carla Rebeca Da Silva Sena, Gabriela Martins Costa Gomes, Noëmi Künstle, Olga Gorlanova, Andrea Marten, Sven Schulzke, Florian Wyler, Vanessa E. Murphy, Paul D. Robinson, Peter D. Sly, Jakob Usemann, Benjamin Stöcklin, Ruth Steinberg, Sophie Yammine, Loretta...
Metabolite Fusion between Breath and Blood Enables More In-Depth Understanding of the Endogenous Metabolome
AUTHORS: Zhifeng Tang, Jianming Yang, Bingtian Su, Xin Xu, Xin Luo, Huiling Wang, Keda Zhang, Tao Huan, Pablo Sinues, Mingliang Fang, *Xue Li* JOURNAL INFO: Analytical Chemistry YEAR: 2025 https://doi.org/10.1021/acs.analchem.5c00543
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