Welcome to the SinuesLab

Translational Research of Today,
Standard Care of Tomorrow

RESEARCH

Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine

Generate HYPOTHESIS

Our interdisciplinary team work coordinately to generate working hypotheses to address our clinical questions

design the experiment

Together with our clinical colleagues we design the right experiment to answer our research questions

measure

We use state-of-the-art high resolution-mass spectrometry to map the exhaled metabolome of our patients

analyze

We use sophisticated bioinformatic tools to decode complex datasets.

validate

Our results are further validated and generate further hypotheses to advance answering our research questions.

ONGOING PROJECTS

DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS

In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.

THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS

The objective in this project is to optimize the therapeutic regimen of pediatric patients to maximize efficacy and minimize side effects.

DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM

In this project we combine air pollution models, state-of-the-art lung function tests and our breath metabolomics approach to better understand the detrimental effects of air pollution exposure in children.

RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS

Our objective is to diagnose infectious diseases, with a focus on pneumonia, by combining our high resolution/high mass accuracy real-time breath analysis technology combined with Artificial Intelligence to provide a positive/negative response within 15 minutes.

News

Join our research team as a PhD candidate for an exciting project in the field of real-time analysis of respiratory gases! Apply now for this fully funded position starting from August 2024. More information: https://jobs.unibas.ch/offene-stellen/doktorand-in/3685bfc1-ca80-475d-863d-4d35488e847b

#PhD #JobOpening #BiomedicalEngineering

Our group member Zhihong Yin has been awarded the Student Travel Award by the Swiss Metabolomics Society @swiss_society ! 🌟 Zhihong will present her work next month at Metabolomics 2024 in Osaka, Japan. The award will support travel and accommodation.🎉 #Metabolomics2024

Call for Abstracts for Metabolomics 2024!

Complete details online: https://www.metabolomics2024.org/abstract-submissions

Deadline for oral abstracts is March 7.

#metabolomics

We had the honor to have a seminar given to our lab by @Patrik_Sp, thank you for the visit and super interesting lecture! #siftms #siftdtms #sesims

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ABOUT US

Research Group
Members

Prof. Dr. Pablo Sinues Ph.D.
Prof. Dr. Pablo Sinues Ph.D.

Head of Translational Medicine Research Group

Dr. Kapil Dev Singh Ph.D.
Dr. Kapil Dev Singh Ph.D.

Senior Scientist

Mélina Richard
Mélina Richard

Research Associate

Noemi Künstle
Noemi Künstle

PhD Candidate

PROJECTS

>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function

DR. JAKOB USEMANN, M.D. Ph.D.
DR. JAKOB USEMANN, M.D. Ph.D.

Resident Physician, Postdoctoral Research Fellow

Isabel Gonzalez
Isabel Gonzalez

Lead Study Nurse

Mana Okada Thommen
Mana Okada Thommen

Study Nurse BILD, EBECA

Moor de Waal
Moor de Waal

Administrative Assistant

m.dewaal@unibas.ch

 

Former Group Members

Mo Awchi, PhD
Mo Awchi, PhD

PhD Candidate

Amanda Gisler, PhD
Amanda Gisler, PhD
PROJECTS

> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis

> Deciphering the Impact of Air Pollution Exposure for the Respiratory System

PUBLICATIONS

Breath-based therapeutic drug monitoring method

AUTHORS: Kapil Dev Singh, Amanda Gisler, Martin Osswald, Malcolm Kohler, Johannes Van Den Anker, Nicolas Von Der Weid, Urs Frey, Alexandre Datta, Pablo Sinues YEAR: 2023 LINK: https://patents.google.com/patent/US20230277125A1/en  

SPINOFF

Spin-off company

Deep Breath Intelligence A.G. is a spin-off company of the University of Basel co-founded by Prof. Pablo Sinues.
DBI’s vision is to uncover the full potential of Molecular Breath Analysis to advance precision medicine and make it available for general health care.
COLLABS
FUNDING