Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Core Members
Group Members
Zhihong Yin
PhD Candidate
Malena Maira Gwerder, MD
PhD Candidate
Diego Manuel Baur
Postdoc
Nachelli Malpica
Master student
PROJECTS
Development of Standard Operating Procedures for Reproducible Offline Breath Analysis
Former Group Members
Noemi Künstle, MD, PhD
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
Jiafa Zeng, PhD
PhD Candidate
Amanda Gisler, PhD
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System
Kim Fabienne Arnold, PhD
Breath Analysis of Propofol and Associated Metabolic Signatures: A Pilot Study Using Secondary Electrospray Ionization High-resolution Mass Spectrometry
AUTHORS: Jiafa Zeng, Nikola Stankovic, Kapil Dev Singh, Regula Steiner, Urs Frey, Thomas Erb, Pablo Sinues JOURNAL INFO: Anesthesiology YEAR: 2025 DOI: 10.1097/ALN.0000000000005531
Patent: Mass spectrometry method and system
AUTHORS: Pablo Sinues, Kapil Dev Singh, Kim Arnold, Xue Li, Xing Chen YEAR: 2025 US20250137994A1
Practical Applications of Secondary/Extractive Electrospray Ionization (SESI): A Versatile Tool for Real-Time Chemical Analysis
AUTHORS: Xin Luo, Huiling Wang, Xiaolan Hu, Sasho Gligorovski, Xue Li, Pablo Sinues JOURNAL INFO: Mass Spectrometry Reviews YEAR: 2025 DOI: 10.1002/mas.21938
Prenatal exposure to air pollution affects autophagy, senescence, and remodelling proteins in cord blood
AUTHORS: Olga Gorlanova, Heide Oller, Uri Nahum, Noëmi Künstle, Loretta Müller, Andrea Marten, Céline Rüttimann, Danielle Vienneau, Kees de Hoogh, Primo Schär, David Schürmann, Carla Rebeca Da Silva Sena, Martin Röösli, Philipp Latzin, Pablo Sinues, Sven Schulzke,...
The Evolution of Secondary/Extractive Electrospray Ionization: From Ionization Mechanism to Instrumental Advances
AUTHORS: Guoyuan Liao, Bo Yang, Lei Li, Xiaolan Hu, Christian George, Abdelwahid Mellouki, Anthony Wexler, Pablo Sinues, Xue Li JOURNAL INFO: Mass Spectrometry Reviews YEAR: 2025 DOI: 10.1002/mas.21931
Urinary marker of oxidative stress in children correlates with molecules in exhaled breath
AUTHORS: Amanda Gisler, Kapil Dev SIngh, Andrea Marten, Fabienne Decrue, Urs Frey, Pablo Sinues and Jakob Usemann JOURNAL INFO: Frontiers in Molecular Biosciences YEAR: 2025 LINK: 10.3389/fmolb.2025.1511119
Molecular breath profile of acute COPD exacerbations
AUTHORS: Sarah Basler, Noriane A. Sievi, Felix Schmidt, Kai Fricke, Alexandra Arvaji, Jonas Herth, Diego Baur, Pablo Sinues, Silvia Ulrich and Malcolm Kohler JOURNAL INFO: Journal of Breath Research YEAR: 2024 LINK: 10.1088/1752-7163/ad9ac4
Pharmacometabolomics via real-time breath analysis captures metabotypes of asthmatic children associated with salbutamol responsiveness
AUTHORS: Jiafa Zeng, Jakob Usemann, Kapil Dev Singh, Anja Jochmann, Daniel Trachsel, Urs Frey, Pablo Sinues JOURNAL INFO: iScience, 2024, 111446, ISSN 2589-0042 YEAR: 2024 LINK: https://doi.org/10.1016/j.isci.2024.111446
Differences in autophagy marker levels at birth in preterm vs. term infants
AUTHORS: Noëmi Künstle, Olga Gorlanova, Andrea Marten, Loretta Müller, Pawan Sharma, Martin Röösli, Pablo Sinues, Primo Schär, David Schürmann, Céline Rüttimann, Carla Rebeca Da Silva Sena, Uri Nahum, Jakob Usemann, Ruth Steinberg, Sophie Yammine, Sven Schulzke,...
Metabolic trajectories of diabetic ketoacidosis onset described by breath analysis
AUTHORS: Mo Awchi, Kapil Dev Singh, Sara Bachmann Brenner, Marie-Anne Burckhardt, Melanie Hess, Jiafa Zeng, Alexandre N. Datta, Urs Frey, Urs Zumsteg, Gabor Szinnai, Pablo Sinues JOURNAL INFO: Frontiers in Endocrinology. 2024, vol. 15 YEAR: 2024 LINK:...
Spin-off company
