Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Jiafa Zeng
PhD Candidate
Zhihong Yin
PhD Candidate
Noemi Künstle
PhD Candidate
PROJECTS
>Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
DR. JAKOB USEMANN, M.D. Ph.D.
Resident Physician, Postdoctoral Research Fellow
Diego Manuel Baur
Postdoc
Former Group Members
Amanda Gisler, PhD
PROJECTS
> Development of Standard Operating Procedures for Reproducible Real-Time Breath Analysis
> Deciphering the Impact of Air Pollution Exposure for the Respiratory System
Kim Fabienne Arnold, PhD
Pharmakokinetik von Medikamenten durch Echtzeit‐Analyse der Atemluft von Mäusen
AUTHORS: X Li, P Martinez‐Lozano Sinues, R Dallmann, L Bregy, M Hollmén, ...JOURNAL INFO: Angewandte Chemie 127 (27), 7926-7929YEAR: 2015LINK https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.201503312
The Effect of CPAP Withdrawal on Exhaled Breath in Obstructive Sleep Apnea-A Randomized Controlled Trial: 26
AUTHORS: E Schwarz, ML Sinues, L Bregy, T Gaisl, M Gaugg, ...JOURNAL INFO: Respiration 89 (5), 450-451YEAR: 2015LINK...
Rapid Discrimination betweenStreptococcus Pneumoniaeand OtherStreptococciby Mass Spectrometric Analysis of Volatile Metabolites: P141
AUTHORS: ML Sinues, L Bregy, R Zenobi, R Zbinden, M KohlerJOURNAL INFO: Respiration 89 (5), 491-492YEAR: 2015LINK...
Identification of 2-alkenals, 4-hydroxy-2-alkenals, and 4-hydroxy-2, 6-alkadienals in exhaled breath condensate by UHPLC-HRMS and in breath by real-time HRMS
AUTHORS: D García-Gómez, P Martínez-Lozano Sinues, C Barrios-Collado, ...JOURNAL INFO: Analytical chemistry 87 (5), 3087-3093YEAR: 2015LINK https://pubs.acs.org/doi/pdf/10.1021/ac504796p
Circadian variation of the human metabolome captured by real-time breath analysis
AUTHORS: P Martinez-Lozano Sinues, L Tarokh, X Li, M Kohler, SA Brown, R Zenobi, ...JOURNAL INFO: PloS one 9 (12), e114422YEAR: 2014LINK https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114422
Ion mobility spectrometry coupled to laser-induced fluorescence for probing the electronic structure and conformation of gas-phase ions
AUTHORS: VE Frankevich, KV Barylyuk, PML Sinues, R ZenobiJOURNAL INFO: Journal of Analytical Chemistry 69 (13), 1215-1219YEAR: 2014LINK https://link.springer.com/content/pdf/10.1134/S106193481413005X.pdf
Rapid identification of bacteria in blood cultures by mass-spectrometric analysis of volatiles
AUTHORS: C Ballabio, S Cristoni, G Puccio, M Kohler, MR Sala, P Brambilla, ...JOURNAL INFO: Journal of clinical pathology 67 (8), 743-746YEAR: 2014LINK https://jcp.bmj.com/content/jclinpath/67/8/743.full.pdf
Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles
AUTHORS: J He, PML Sinues, M Hollmén, X Li, M Detmar, R ZenobiJOURNAL INFO: Scientific reports 4 (1), 1-6YEAR: 2014LINK https://www.nature.com/articles/srep05196
Rapid Characterization of Oral Bacterial Cultures: P124
AUTHORS: P Sinues, X Li, A Müggler, L Bregy, G Belibasakis, R Zenobi, M Kohler, ...JOURNAL INFO: Respiration 87 (6), 552-553YEAR: 2014LINK...
Determination of Smoking Status by Real-Time Mass Spectrometry: P135
AUTHORS: P Sinues, X Li, N Sievi, R Zenobi, M KohlerJOURNAL INFO: Respiration 87 (6)YEAR: 2014LINK https://www.zora.uzh.ch/id/eprint/131026/1/ZORA131026.pdf
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