Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Core Members
Group Members
Zhihong Yin
PhD Candidate
Former Group Members
Dr. Nachelli Malpica
Former Master Student
PROJECTS
> Development of Standard Operating Procedures for Reproducible Offline Breath Analysis
Dr. Malena Maira Gwerder, MD
Former PhD Candidate
PROJECTS
> Bern Basel Infant Lung Development (BILD) cohort
NEXT
> Assistant Pediatric Doctor at UKBB
Dr. Mo Awchi
Former PhD Candidate
PROJECTS
> Therapeutic Drug Monitoring Guided by Breath Analysis
NEXT
> Senior Operational Specialist at Lonza
Isabel Gonzalez
Former Lead Study Nurse
Dr. Diego Manuel Baur
Former Postdoctoral Researcher
Moor de Waal
Former Student Assistant
Dr. Amanda Gisler
Former PhD Student
PROJECTS
> Standardizing Real-Time Breath Analysis
> Impact of Air Pollution on the Respiratory System
NEXT
> Management Board Member, LUSTAT Statistics
Fabienne Decrue
Former Responsible Pediatric Doctor
PROJECTS
> Standardisation of Mass Spectrometer Offline Sampling
NEXT
> Pediatric Doctor at UKBB
Dr. Noemi Künstle, MD
Former PhD Candidate
PROJECTS
> Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
Dr. Jiafa Zeng
Former PhD Candidate
Dr. Kim Fabienne Arnold
Former PhD Student
Expanding metabolite coverage of real-time breath analysis by coupling a universal secondary electrospray ionization source and high resolution mass spectrometry—a pilot study …
AUTHORS: MT Gaugg, DG Gomez, C Barrios-Collado, G Vidal-de-Miguel, M Kohler, ...JOURNAL INFO: Journal of breath research 10 (1), 016010YEAR: 2016LINK https://iopscience.iop.org/article/10.1088/1752-7155/10/1/016010/pdf
Effects of CPAP therapy withdrawal on exhaled breath pattern in obstructive sleep apnoea
AUTHORS: EI Schwarz, PML Sinues, L Bregy, T Gaisl, DG Gomez, MT Gaugg, Y Suter, ...JOURNAL INFO: Thorax 71 (2), 110-117YEAR: 2016LINK https://thorax.bmj.com/content/thoraxjnl/71/2/110.full.pdf
Numerical modeling and experimental validation of a universal secondary electrospray ionization source for mass spectrometric gas analysis in real-time
AUTHORS: C Barrios-Collado, G Vidal-de-Miguel, PML SinuesJOURNAL INFO: Sensors and Actuators B: Chemical 223, 217-225YEAR: 2016LINK https://www.sciencedirect.com/science/article/pii/S0925400515303804
Secondary electrospray ionization coupled to high-resolution mass spectrometry reveals tryptophan pathway metabolites in exhaled human breath
AUTHORS: D García-Gómez, T Gaisl, L Bregy, PML Sinues, M Kohler, R ZenobiJOURNAL INFO: Chemical Communications 52 (55), 8526-8528YEAR: 2016LINK https://iopscience.iop.org/article/10.1088/1752-7155/9/3/031001/pdf
Differentiation of oral bacteria in in vitro cultures and human saliva by secondary electrospray ionization–mass spectrometry
AUTHORS: L Bregy, AR Müggler, PML Sinues, D García-Gómez, Y Suter, ...JOURNAL INFO: Scientific reports 5 (1), 1-10YEAR: 2015LINK https://erj.ersjournals.com/content/46/suppl_59/OA1749
Secondary electrospray ionization-mass spectrometry and a novel statistical bioinformatic approach identifies a cancer-related profile in exhaled breath of breast cancer …
AUTHORS: PML Sinues, E Landoni, R Miceli, VF Dibari, M Dugo, R Agresti, ...JOURNAL INFO: Journal of breath research 9 (3), 031001YEAR: 2015LINK https://patentimages.storage.googleapis.com/e5/87/96/105b32cef03209/US9121844.pdf
The effect of CPAP withdrawal on exhaled breath in OSA–A randomised controlled trial
AUTHORS: EI Schwarz, PML Sinues, L Bregy, DG Gomez, T Gaisl, M Gaugg, ...JOURNAL INFO: European Respiratory Journal 46 (suppl 59)YEAR: 2015LINK...
Method to analyze and classify persons and organisms based on odor patterns from released vapors
AUTHORS: PML Sinues, JF De La MoraJOURNAL INFO: US Patent 9,121,844YEAR: 2015LINK https://patentimages.storage.googleapis.com/e5/87/96/105b32cef03209/US9121844.pdf
Drug pharmacokinetics determined by real‐time analysis of mouse breath
AUTHORS: X Li, P Martinez‐Lozano Sinues, R Dallmann, L Bregy, M Hollmén, ...JOURNAL INFO: Angewandte Chemie International Edition 54 (27), 7815-7818YEAR: 2015LINK https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.201503312
Pharmakokinetik von Medikamenten durch Echtzeit‐Analyse der Atemluft von Mäusen
AUTHORS: X Li, P Martinez‐Lozano Sinues, R Dallmann, L Bregy, M Hollmén, ...JOURNAL INFO: Angewandte Chemie 127 (27), 7926-7929YEAR: 2015LINK https://onlinelibrary.wiley.com/doi/pdf/10.1002/ange.201503312
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