Translational Research of Today,
Standard Care of Tomorrow
Unleashing the Full Potential of Breath Metabolomics to Advance Precision Medicine
Generate HYPOTHESIS
design the experiment
measure
analyze
validate
ONGOING PROJECTS
DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH ANALYSIS
In this project we develop the necessary procedures to ensure the highest data quality possible, enabling multi-center studies.
THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS
DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM
RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS
News
Research Group
Members
Core Members
Group Members
Zhihong Yin
PhD Candidate
Former Group Members
Dr. Nachelli Malpica
Former Master Student
PROJECTS
> Development of Standard Operating Procedures for Reproducible Offline Breath Analysis
Dr. Malena Maira Gwerder, MD
Former PhD Candidate
PROJECTS
> Bern Basel Infant Lung Development (BILD) cohort
NEXT
> Assistant Pediatric Doctor at UKBB
Dr. Mo Awchi
Former PhD Candidate
PROJECTS
> Therapeutic Drug Monitoring Guided by Breath Analysis
NEXT
> Senior Operational Specialist at Lonza
Isabel Gonzalez
Former Lead Study Nurse
Dr. Diego Manuel Baur
Former Postdoctoral Researcher
Moor de Waal
Former Student Assistant
Dr. Amanda Gisler
Former PhD Student
PROJECTS
> Standardizing Real-Time Breath AnalysisÂ
> Impact of Air Pollution on the Respiratory System
NEXT
> Management Board Member, LUSTAT Statistics
Fabienne Decrue
Former Responsible Pediatric Doctor
PROJECTS
> Standardisation of Mass Spectrometer Offline Sampling
NEXT
> Pediatric Doctor at UKBB
Dr. Noemi Künstle, MD
Former PhD Candidate
PROJECTS
> Differences in markers of oxidative stress response, autophagy, cellular senescence and remodeling in cord blood in preterm infants compared to term infants and their correlation with air pollution and lung function
Dr. Jiafa Zeng
Former PhD Candidate
Dr. Kim Fabienne Arnold
Former PhD Student
Comparison of Plasma Ionization- and Secondary Electrospray Ionization- High-resolution Mass Spectrometry for Real-time Breath Analysis
Comparison of Plasma Ionization- and Secondary Electrospray Ionization- High-resolution Mass Spectrometry for Real-time Breath Analysis AUTHORS: Jiafa Zeng, Alexandra Christen, Kapil Dev Singh, Urs Frey, Pablo Sinues JOURNAL INFO:Â Chimia 2022 YEAR: 2022 LINK:...
Personalized Medicine, Curated Collections
Human Breath Analysis May Support the Existence of Individual Metabolic Phenotypes AUTHORS: Pablo Martinez-Lozano Sinues, Malcolm Kohler, Renato Zenobi JOURNAL INFO:Â PLOS ONE, Curated Collections YEAR: 2022 (2013) LINK:...
In vivo detection of metabolic 2H-incorporation upon ingestion of 2H2O
AUTHORS: Arnold, Kim; Chen, Xing; Zhang, Hui; Singh, Kapil Dev; Yin, Zhihong; Yao, Yao; Luan, Tiangang; Sinues, Pablo*; Li, Xue* JOURNAL INFO: Â Journal of Bio-X Research YEAR: 2022 LINK:...
Rapid Detection of Staphylococcus aureus and Streptococcus pneumoniae by Real-Time Analysis of Volatile Metabolites
AUTHORS: Alejandro Gómez-Mejia, Arnold Kim, Bär Julian, Kapil Dev Singh, Thomas C. Scheier, Silvio D. Brugger, Annelies S. Zinkernagel, Pablo Sinues JOURNAL INFO: iScience YEAR: 2022 LINK: https://doi.org/10.1016/j.isci.2022.105080
An Interoperability Framework for Multicentric Breath Metabolomic Studies
AUTHORS: Gisler, Amanda; Singh, Kapil Dev;Â Zeng, Jiafa;Â Osswald, Martin; Awchi, Mo;Â Decrue, Fabienne;Â Schmidt, Felix;Â Sievi, Noriane; Chen, Xing; Usemann, Jakob; Frey, Urs; Kohler, Malcolm; Li, Xue; Sinues, Pablo. JOURNAL INFO: iScience YEAR: 2022 LINK:...
Pollen exposure is associated with risk of respiratory symptoms during the first year of life
AUTHORS: Gisler A, Eeftens M, de Hoogh K, Vienneau D, Salem Y, Yammine S, Jakob J, Gorlanova O, Decrue F, Gehrig R, Frey U, Latzin P, Fuchs O, Usemann J; BILD study group JOURNAL INFO: Allergy. 2022 Mar 18 YEAR: 2022 LINK: https://doi.org/10.1111/all.15284
Combination of Exhaled Breath Analysis with Parallel Lung Function and FeNO Measurements in Infants
AUTHORS: Fabienne Decrue, Kapil Dev Singh, Amanda Gisler, Mo Awchi, Jiafa Zeng, Jakob Usemann, Urs Frey, Pablo Sinues. JOURNAL INFO: Anal. Chem. 2021, 93, 47, 15579–15583 YEAR: 2021 LINK: https://doi.org/10.1021/acs.analchem.1c02036
Real-Time Monitoring of Metabolism during Exercise by Exhaled Breath
AUTHORS: Osswald M, Kohlbrenner D, Nowak N, Spörri J, Sinues P, Nieman D, Sievi NA, Scherr J, Kohler M. JOURNAL INFO:  Metabolites. 2021; 11(12):856. YEAR: 2021 LINK: https://doi.org/10.3390/metabo11120856
Quantification of volatile organic compounds by secondary electrospray ionization-high resolution mass spectrometry
AUTHORS: ChaoLiu, JiafaZeng, PabloSinues, MingliangFang, ZhenZhou, XueLi JOURNAL INFO: Analytica Chimica Acta, Volume 1180, 2 October 2021, 338876 YEAR: 2021 LINK: https://pubs.acs.org/doi/10.1021/acs.analchem.1c00509
Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Nonvolatile Drugs from Blood to Breath
AUTHORS: Xing ChenXing Chen, Keda Zhang, Zhihong Yin, Mingliang Fang, Weidan Pu, Zhening Liu, Lei Li, Pablo Sinues, Robert Dallmann, Zhen Zhou, Xue Li JOURNAL INFO: Anal. Chem. 2021, 93, 12, 5005–5008 YEAR: 2021 LINK:...
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